Ionotropic and metabotropic glutamate receptor structure and pharmacology (Q36054635)

11 August 2017

1 reference

title

Ionotropic and metabotropic glutamate receptor structure and pharmacology (English)

1 reference

11 August 2017

1 reference

James N C Kew

1

1 reference

11 August 2017

John A Kemp

series ordinal

2

1 reference

11 August 2017

publication date

25 February 2005

1 reference

11 August 2017

1 reference

11 August 2017

volume

179

1 reference

11 August 2017

issue

1

1 reference

11 August 2017

page(s)

4-29

1 reference

Distribution of neurones expressing inwardly rectifying and Ca(2+)-permeable AMPA receptors in rat hippocampal slices.

11 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-2200-Z

Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-2200-Z

Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-2200-Z

Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-2200-Z

N-methyl-D-aspartic acid receptor structure and function

21 January 2018

1 reference

12 December 2020

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats

1 reference

12 December 2020

N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells

1 reference

12 December 2020

NMDA receptor antagonists. A new therapeutic approach for Alzheimer's disease.

1 reference

12 December 2020

YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist.

1 reference

12 December 2020

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

1 reference

12 December 2020

Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel

1 reference

12 December 2020

Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

1 reference

12 December 2020

CX-516 Cortex pharmaceuticals.

1 reference

12 December 2020

Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor

1 reference

12 December 2020

1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors

1 reference

12 December 2020

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits

1 reference

12 December 2020

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

1 reference

12 December 2020

The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.

1 reference

12 December 2020

The glutamate receptor ion channels

1 reference

12 December 2020

Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.

1 reference

12 December 2020

Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala

1 reference

12 December 2020

[3H]homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site

1 reference

12 December 2020

Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine

1 reference

12 December 2020

N-Glycosylation is not a prerequisite for glutamate receptor function but Is essential for lectin modulation.

1 reference

12 December 2020

Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D-aspartic acid receptor complex

1 reference

12 December 2020

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

12 December 2020

Stimulatory and inhibitory properties of aminoglycoside antibiotics at N-methyl-D-aspartate receptors.

1 reference

12 December 2020

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

1 reference

12 December 2020

(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

1 reference

12 December 2020

The tetrameric structure of a glutamate receptor channel

1 reference

12 December 2020

Developmental changes in distribution of NMDA receptor channel subunit mRNAs.

1 reference

12 December 2020

[3H]N-2-(4-(N-benzamido)phenyl)propyl-2-propanesulfonamide: a novel AMPA receptor potentiator and radioligand

1 reference

12 December 2020

Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist

1 reference

12 December 2020

Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain

1 reference

12 December 2020

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

1 reference

12 December 2020

N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors

1 reference

12 December 2020

Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site.

1 reference

12 December 2020

The glycine site of the NMDA receptor--five years on.

1 reference

12 December 2020

Direct and indirect modulation of the N-methyl D-aspartate receptor

1 reference

12 December 2020

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam

1 reference

12 December 2020

Peripheral group I metabotropic glutamate receptors modulate nociception in mice

1 reference

12 December 2020

A desensitization-selective potentiator of AMPA-type glutamate receptors

1 reference

12 December 2020

Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents.

1 reference

12 December 2020

New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neurons

1 reference

12 December 2020

Metabotropic glutamate receptor 5 is a disulfide-linked dimer

1 reference

12 December 2020

A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide.

1 reference

12 December 2020

Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents

1 reference

12 December 2020

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

1 reference

12 December 2020

2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

1 reference

12 December 2020

Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability.

1 reference

12 December 2020

ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

1 reference

12 December 2020

NMDA receptor pathways as drug targets

1 reference

12 December 2020

(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo

1 reference

12 December 2020

Kainate receptor agonists, antagonists and allosteric modulators

1 reference

12 December 2020

Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists

1 reference

12 December 2020

Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors

1 reference

12 December 2020

Modulation and block of ion channels: a new biology of polyamines

1 reference

12 December 2020

The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression

1 reference

12 December 2020

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1 reference

12 December 2020

In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors.

1 reference

12 December 2020

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

1 reference

12 December 2020

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

1 reference

12 December 2020

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

1 reference

12 December 2020

Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists

1 reference

12 December 2020

AMPA receptor modulators as cognitive enhancers

1 reference

12 December 2020

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.

1 reference

12 December 2020

6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor

1 reference

12 December 2020

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1 reference

12 December 2020

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo

1 reference

12 December 2020

GluR5 Kainate Receptors, Seizures, and the Amygdala

1 reference

12 December 2020

The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischaemia

1 reference

12 December 2020

AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels

1 reference

12 December 2020

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

1 reference

12 December 2020

Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.

1 reference

12 December 2020

Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.

1 reference

12 December 2020

Molecular physiology of kainate receptors

1 reference

12 December 2020

(2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist

1 reference

12 December 2020

Acquired QT interval prolongation and HERG: implications for drug discovery and development

1 reference

12 December 2020

The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain

1 reference

12 December 2020

Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site

1 reference

12 December 2020

Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor

1 reference

12 December 2020

4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

1 reference

12 December 2020

Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors

1 reference

12 December 2020

The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats

1 reference

12 December 2020

Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats

1 reference

12 December 2020

3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus

1 reference

12 December 2020

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

1 reference

12 December 2020

Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus

1 reference

12 December 2020

Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex.

1 reference

12 December 2020

Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus

1 reference

12 December 2020

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

1 reference

12 December 2020

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

1 reference

12 December 2020

The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential

1 reference

12 December 2020

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

1 reference

12 December 2020

Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.

1 reference

12 December 2020

Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid

1 reference

12 December 2020

Progressive sequence alignment as a prerequisite to correct phylogenetic trees

1 reference

12 December 2020

Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist

1 reference

12 December 2020

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

1 reference

12 December 2020

mGlu5 receptor antagonists: a novel class of anxiolytics?

1 reference

12 December 2020

Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor

1 reference

12 December 2020

Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice

1 reference

12 December 2020

Regulation of neurotransmitter release by metabotropic glutamate receptors

1 reference

12 December 2020

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

1 reference

12 December 2020

Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket

1 reference

12 December 2020

Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner

1 reference

12 December 2020

Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins

1 reference

12 December 2020

Membrane topology of a metabotropic glutamate receptor

1 reference

12 December 2020

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

1 reference

12 December 2020

4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists

1 reference

12 December 2020

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1 reference

12 December 2020

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

12 December 2020

Molecular determinants of high affinity binding to group III metabotropic glutamate receptors

1 reference

12 December 2020

5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition

1 reference

12 December 2020

Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors

1 reference

12 December 2020

(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses

1 reference

12 December 2020

Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate

1 reference

12 December 2020

Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits.

1 reference

12 December 2020

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists

1 reference

12 December 2020

Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist

1 reference

12 December 2020

Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits.

1 reference

12 December 2020

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist

1 reference

12 December 2020

Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A

1 reference

12 December 2020

Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids

1 reference

12 December 2020

Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors

1 reference

12 December 2020

Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists

1 reference

12 December 2020

Assembly and cell surface expression of KA-2 subunit-containing kainate receptors

1 reference

12 December 2020

Structure of the metabotropic glutamate receptor

1 reference

12 December 2020

Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo

1 reference

12 December 2020

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

1 reference

12 December 2020

Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

1 reference

12 December 2020

Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy

1 reference

12 December 2020

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes

1 reference

12 December 2020

The AMPA receptor binding site: focus on agonists and competitive antagonists

1 reference

12 December 2020

[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

1 reference

12 December 2020

CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo

1 reference

12 December 2020

Activity-dependent change in AMPA receptor properties in cerebellar stellate cells.

1 reference

12 December 2020

The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

1 reference

12 December 2020

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5

1 reference

12 December 2020

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists

1 reference

12 December 2020

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

1 reference

12 December 2020

Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit

1 reference

12 December 2020

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

1 reference

12 December 2020

Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate

1 reference

12 December 2020

Mechanism of glutamate receptor desensitization

1 reference

12 December 2020

Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466

1 reference

12 December 2020

Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors

1 reference

12 December 2020

A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity

1 reference

12 December 2020

Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1.

1 reference

12 December 2020

Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist

1 reference

12 December 2020

LY339434, a GluR5 kainate receptor agonist

1 reference

12 December 2020

1 reference

12 December 2020

Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action

1 reference

12 December 2020

NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles

1 reference

12 December 2020

Non-competitive AMPA antagonists of 2,3-benzodiazepine type

1 reference

12 December 2020

Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state

1 reference

12 December 2020

Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block

1 reference

12 December 2020

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

1 reference

12 December 2020

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

12 December 2020

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

1 reference

12 December 2020

Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines

1 reference

12 December 2020

Polyamine-like actions of aminoglycosides at recombinant N-methyl-D-aspartate receptors.

1 reference

12 December 2020

Negative cooperativity of glutamate binding in the dimeric metabotropic glutamate receptor subtype 1.

1 reference

12 December 2020

Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

1 reference

12 December 2020

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

1 reference

12 December 2020

AMPA receptor potentiators for the treatment of CNS disorders

1 reference

12 December 2020

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

1 reference

12 December 2020

Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn

1 reference

12 December 2020

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

1 reference

12 December 2020

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1 reference

12 December 2020

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

1 reference

12 December 2020

In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.

1 reference

12 December 2020

Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor

1 reference

12 December 2020

Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-d-aspartate receptor

1 reference

12 December 2020

Regulation of ion channel/neurotransmitter receptor function by RNA editing

1 reference

12 December 2020

Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors

1 reference

12 December 2020

An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones

1 reference

12 December 2020

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

1 reference

12 December 2020

LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease.

1 reference

12 December 2020

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

1 reference

12 December 2020

Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia?

1 reference

12 December 2020

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

1 reference

12 December 2020

Astrocyte-mediated activation of neuronal kainate receptors

1 reference

12 December 2020

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

1 reference

12 December 2020

LY404187: a novel positive allosteric modulator of AMPA receptors

1 reference

12 December 2020

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

1 reference

12 December 2020

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

1 reference

12 December 2020

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

1 reference

12 December 2020

NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins

1 reference

12 December 2020

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

1 reference

12 December 2020

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1 reference

12 December 2020

Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist.

1 reference

12 December 2020

Orally efficacious NR2B-selective NMDA receptor antagonists

1 reference

12 December 2020

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1 reference

12 December 2020

Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists

1 reference

12 December 2020

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord

1 reference

12 December 2020

Molecular diversity of the NMDA receptor channel

1 reference

12 December 2020

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

1 reference

12 December 2020

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

1 reference

12 December 2020

Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist

1 reference

12 December 2020

Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles

1 reference

12 December 2020

Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro

1 reference

12 December 2020

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

1 reference

12 December 2020

Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine

1 reference

12 December 2020

Glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+

1 reference

12 December 2020

Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.

1 reference

12 December 2020

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

1 reference

12 December 2020

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

1 reference

12 December 2020

Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors

1 reference

12 December 2020

Structure and function of glutamate receptor ion channels

1 reference

12 December 2020

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

1 reference

12 December 2020

In-vitro characterization of YM872, a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist.

1 reference

12 December 2020

L-687,414, a low efficacy NMDA receptor glycine site partial agonist in vitro, does not prevent hippocampal LTP in vivo at plasma levels known to be neuroprotective

1 reference

12 December 2020

A crossover, add-on trial of talampanel in patients with refractory partial seizures

1 reference

12 December 2020

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1 reference

12 December 2020

6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor

1 reference

12 December 2020

Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.

1 reference

12 December 2020

Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit

1 reference

12 December 2020

State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist

1 reference

12 December 2020

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

1 reference

12 December 2020

Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain.

1 reference

12 December 2020

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

1 reference

12 December 2020

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1 reference

12 December 2020

Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators

1 reference

12 December 2020

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

1 reference

12 December 2020

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

1 reference

12 December 2020

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

1 reference

12 December 2020

Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors

1 reference

12 December 2020

Kainate receptors are involved in synaptic plasticity

1 reference

12 December 2020

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1 reference

12 December 2020

mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

1 reference

12 December 2020

10.1007/S00213-005-2200-Z

Identifiers

DOI

1 reference

11 August 2017

1 reference