Molecular mechanism and cellular function of MHCII ubiquitination (Q27010579)

Jeoung-Sook Shin

series ordinal

2

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language of work or name

1 reference

July 2015

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published in

Immunological Reviews

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volume

266

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issue

1

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page(s)

134-44

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Ubiquitin in the immune system

cites work

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Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

21 March 2017

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Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

21 March 2017

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Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells

21 March 2017

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21 March 2017

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Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface

21 March 2017

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Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)

21 March 2017

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Interleukin-10-deficient mice develop chronic enterocolitis

7 April 2017

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7 April 2017

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Dendritic cells: specialized and regulated antigen processing machines

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Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus

7 April 2017

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Cutting edge: Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation

28 September 2017

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Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

28 September 2017

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MHC class II antigen presentation by dendritic cells regulated through endosomal sorting

28 September 2017

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Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation

28 September 2017

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Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism

28 September 2017

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Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection

28 September 2017

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MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

28 September 2017

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Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR.

28 September 2017

1 reference

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B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

28 September 2017

1 reference

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A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.

28 September 2017

1 reference

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Structural requirements for recognition of major histocompatibility complex class II by membrane-associated RING-CH (MARCH) protein E3 ligases

28 September 2017

1 reference

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MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Selection of regulatory T cells in the thymus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Decisions about dendritic cells: past, present, and future

28 September 2017

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What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin-mediated receptor regulation?

28 September 2017

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Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy

28 September 2017

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Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins

28 September 2017

1 reference

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Ubiquitin makes its mark on immune regulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Dendritic Cell Activation Prevents MHC Class II Ubiquitination and Promotes MHC Class II Survival Regardless of the Activation Stimulus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes

28 September 2017

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Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase

28 September 2017

1 reference

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Cutting Edge: Hematopoietic-Derived APCs Select Regulatory T Cells in Thymus

28 September 2017

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Antigen presentation in the thymus for positive selection and central tolerance induction

28 September 2017

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Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Ubiquitylation in innate and adaptive immunity.

28 September 2017

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Dendritic cells in the thymus contribute to T-regulatory cell induction

28 September 2017

1 reference

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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

28 September 2017

1 reference

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A two-step process for thymic regulatory T cell development.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

MHC class II molecules on the move for successful antigen presentation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

MARCH-IX mediates ubiquitination and downregulation of ICAM-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

A novel family of membrane-bound E3 ubiquitin ligases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Cell biology of antigen processing in vitro and in vivo

28 September 2017

1 reference

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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

28 September 2017

1 reference

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Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

28 September 2017

1 reference

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Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis

28 September 2017

1 reference

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MHC class II signaling in antigen-presenting cells

28 September 2017

1 reference

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IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis

28 September 2017

1 reference

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Positive and negative selection of T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation

28 September 2017

1 reference

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Signaling by CD40 and its mimics in B cell activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Distinct antigen MHC class II complexes generated by separate processing pathways.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Control of MHC class II gene expression in autoimmune, infectious, and neoplastic diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Tollip-induced down-regulation of MARCH1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Mediation by HLA-DM of dissociation of peptides from HLA-DR

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Antigen presentation mediated by recycling of surface HLA-DR molecules.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4677682

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.

31 May 2018

1 reference

Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules

21 January 2018

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T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

21 January 2018

1 reference

Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

21 January 2018

1 reference

MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways.

21 January 2018

1 reference

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

21 January 2018

1 reference

Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells.

21 January 2018

1 reference

The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

1 reference

c-MIR, a Human E3 Ubiquitin Ligase, Is a Functional Homolog of Herpesvirus Proteins MIR1 and MIR2 and Has Similar Activity

21 January 2018

1 reference

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

21 January 2018

1 reference

Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

21 January 2018

1 reference

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

21 January 2018

1 reference

Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: roles of interleukin-10 in disease progression and recovery

21 January 2018

1 reference

12 December 2020

CD40 ligation conditions dendritic cell antigen-presenting function through sustained activation of NF-kappaB

1 reference

12 December 2020

IL-10-Deficient B10.Q Mice Develop More Severe Collagen-Induced Arthritis, but Are Protected from Arthritis Induced with Anti-Type II Collagen Antibodies

1 reference

12 December 2020

Modified immunological status of anti-IL-10 treated mice

1 reference

12 December 2020

Autoregulation of MARCH1 expression by dimerization and autoubiquitination

1 reference

12 December 2020

Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor

1 reference

12 December 2020

Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein

1 reference

12 December 2020