Antigen presentation in the thymus for positive selection and central tolerance induction (Q37638193)

21 August 2017

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title

Antigen presentation in the thymus for positive selection and central tolerance induction (English)

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21 August 2017

Ludger Klein

1

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21 August 2017

Maria Hinterberger

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2

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21 August 2017

Gerald Wirnsberger

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3

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21 August 2017

Bruno Kyewski

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4

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21 August 2017

1 December 2009

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Nature Reviews Immunology

21 August 2017

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21 August 2017

9

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21 August 2017

833-844

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21 August 2017

12

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

21 August 2017

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TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation

31 March 2020

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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

31 March 2020

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

31 March 2020

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Differentiation of regulatory Foxp3+ T cells in the thymic cortex

31 March 2020

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31 March 2020

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Comparison of peptides bound to spleen and thymus class II.

31 March 2020

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Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

31 March 2020

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Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture

31 March 2020

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Evidence for a differential avidity model of T cell selection in the thymus

31 March 2020

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Positive and negative thymocyte selection induced by different concentrations of a single peptide

31 March 2020

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Mature T cell reactivity altered by peptide agonist that induces positive selection

31 March 2020

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T cell receptor antagonist peptides induce positive selection

31 March 2020

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T-cell-receptor affinity and thymocyte positive selection

31 March 2020

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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

31 March 2020

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Identification of a naturally occurring ligand for thymic positive selection

31 March 2020

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An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

31 March 2020

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Rare, structurally homologous self-peptides promote thymocyte positive selection

31 March 2020

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Selecting and maintaining a diverse T-cell repertoire

31 March 2020

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Positive and negative selection of T cells

31 March 2020

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Lysosomal cysteine proteases regulate antigen presentation

31 March 2020

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Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

31 March 2020

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Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands

31 March 2020

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Requirement for diverse, low-abundance peptides in positive selection of T cells

31 March 2020

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The imprint of intrathymic self-peptides on the mature T cell receptor repertoire

31 March 2020

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Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice

31 March 2020

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The repertoire of T cells shaped by a single MHC/peptide ligand.

31 March 2020

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Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus

31 March 2020

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Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation.

31 March 2020

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Prss16 is not required for T-cell development

31 March 2020

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Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes

31 March 2020

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Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex

31 March 2020

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Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells

31 March 2020

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Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

31 March 2020

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Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

31 March 2020

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Self-antigen presentation by thymic stromal cells: a subtle division of labor

31 March 2020

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Enhancing immunity through autophagy

31 March 2020

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

31 March 2020

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Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

31 March 2020

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Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules

31 March 2020

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Regulation of CD8+ T cell development by thymus-specific proteasomes

31 March 2020

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Thymoproteasome: probable role in generating positively selecting peptides

31 March 2020

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The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

31 March 2020

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T cells as a self-referential, sensory organ

31 March 2020

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

31 March 2020

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Thymic emigration revisited

31 March 2020

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CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.

31 March 2020

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Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress

31 March 2020

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Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

31 March 2020

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Dependence of self-tolerance on TRAF6-directed development of thymic stroma

31 March 2020

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The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

31 March 2020

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The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

31 March 2020

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Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

31 March 2020

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RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

31 March 2020

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Illegitimate transcription: transcription of any gene in any cell type

31 March 2020

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Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity

31 March 2020

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Are tissues a patch quilt of ectopic gene expression?

31 March 2020

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A central role for central tolerance

31 March 2020

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Projection of an immunological self shadow within the thymus by the aire protein

31 March 2020

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

31 March 2020

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31 March 2020

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Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

31 March 2020

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Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

31 March 2020

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Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.

31 March 2020

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Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

31 March 2020

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

31 March 2020

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T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node

31 March 2020

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The impact of negative selection on thymocyte migration in the medulla.

31 March 2020

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Dead man walking: how thymocytes scan the medulla.

31 March 2020

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Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

31 March 2020

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Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

31 March 2020

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

31 March 2020

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The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

31 March 2020

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Steady-state and inflammatory dendritic-cell development

31 March 2020

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Heterogeneity of thymic dendritic cells

31 March 2020

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Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

31 March 2020

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Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions.

31 March 2020

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Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

31 March 2020

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Distinct functional capacities of mouse thymic and splenic dendritic cell populations.

31 March 2020

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Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

31 March 2020

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Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice

31 March 2020

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Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus

31 March 2020

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Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells

31 March 2020

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Origin of dendritic cells in peripheral lymphoid organs of mice.

31 March 2020

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Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival

31 March 2020

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Dendritic cells in the thymus contribute to T-regulatory cell induction

31 March 2020

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Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

31 March 2020

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On the complexity of self

31 March 2020

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Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells

31 March 2020

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On the intrathymic intercellular transfer of self-determinants.

31 March 2020

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T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form.

31 March 2020

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Intercellular MHC transfer between thymic epithelial and dendritic cells

31 March 2020

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Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome

31 March 2020

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Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

31 March 2020

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Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

31 March 2020

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Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development

31 March 2020

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Exosomes: composition, biogenesis and function

31 March 2020

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Dendritic cells acquire antigens from live cells for cross-presentation to CTL.

31 March 2020

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Cross-presentation by intercellular peptide transfer through gap junctions.

31 March 2020

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The adaptive phenotype of cortical thymic epithelial cells

31 March 2020

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Protein turnover via autophagy: implications for metabolism

31 March 2020

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

31 March 2020

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The role of autophagy in mammalian development: cell makeover rather than cell death

31 March 2020

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Autophagy genes in immunity

31 March 2020

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Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules

31 March 2020

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Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy

31 March 2020

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Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

31 March 2020

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Autophagy promotes MHC class II presentation of peptides from intracellular source proteins

31 March 2020

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Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes

31 March 2020

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Proteasome and peptidase function in MHC-class-I-mediated antigen presentation

31 March 2020

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The neuroendocrine thymus: coexistence of oxytocin and neurophysin in the human thymus

31 March 2020

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T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

31 March 2020

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Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

31 March 2020

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

31 March 2020

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Positional cloning of the APECED gene

31 March 2020

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Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment

31 March 2020

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Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.

31 March 2020

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Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation

31 March 2020

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Several different cell surface molecules control negative selection of medullary thymocytes

31 March 2020

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Negative selection in the thymus includes semimature T cells

31 March 2020

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Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.

31 March 2020

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12 December 2020

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

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12 December 2020

Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells.

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12 December 2020

Cutting edge: thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation

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12 December 2020

Identifiers

DOI

10.1038/NRI2669

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21 August 2017

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