TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities (Q27022062)

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Jessica M. Overstreet

series ordinal

2

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Paul J. Higgins

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3

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Crossref

language of work or name

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January 2013

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25

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issue

1

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page(s)

264-8

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression

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siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

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Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing

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Blinded by the Light: The Growing Complexity of p53

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

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Targeting NOX enzymes in pulmonary fibrosis

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Role of reactive oxygen species in transforming growth factor-beta1-induced extracellular matrix accumulation in renal tubular epithelial cells.

28 September 2017

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PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.

28 September 2017

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Nox enzymes and oxidative stress in atherosclerosis

28 September 2017

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Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis

28 September 2017

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Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

28 September 2017

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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

28 September 2017

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Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis

28 September 2017

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NOX isoforms and reactive oxygen species in vascular health

28 September 2017

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A key role for NOX4 in epithelial cell death during development of lung fibrosis.

28 September 2017

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The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice

28 September 2017

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Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

28 September 2017

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A glimpse of various pathogenetic mechanisms of diabetic nephropathy

28 September 2017

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NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair

28 September 2017

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Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathic pulmonary fibrosis

28 September 2017

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NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology

28 September 2017

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Oxidative stress in obstructive nephropathy

28 September 2017

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NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts.

28 September 2017

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Macrophages and renal fibrosis

28 September 2017

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Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice

28 September 2017

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Posttranslational modification of p53: cooperative integrators of function

28 September 2017

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Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

28 September 2017

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PAI-1 mediates the TGF-beta1+EGF-induced "scatter" response in transformed human keratinocytes

28 September 2017

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Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF.

28 September 2017

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Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts.

28 September 2017

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PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma

28 September 2017

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Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies

28 September 2017

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Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries

28 September 2017

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The hypoxia-inducible factor-2alpha is stabilized by oxidative stress involving NOX4.

28 September 2017

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NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts

28 September 2017

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NADPH oxidases: functions and pathologies in the vasculature

28 September 2017

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NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.

28 September 2017

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Nox proteins in signal transduction

28 September 2017

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Renal gene and protein expression signatures for prediction of kidney disease progression

28 September 2017

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The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases.

28 September 2017

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Regulation of cell proliferation by NADPH oxidase-mediated signaling: potential roles in tissue repair, regenerative medicine and tissue engineering

28 September 2017

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NOX enzymes as novel targets for drug development

28 September 2017

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Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy

28 September 2017

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TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling

28 September 2017

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Atherosclerosis and oxidative stress

28 September 2017

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Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis

28 September 2017

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Biochemical-molecular markers in unilateral ureteral obstruction.

28 September 2017

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28 September 2017

NOX in liver fibrosis

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Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.

28 September 2017

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The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.

28 September 2017

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Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action

28 September 2017

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

28 September 2017

1 reference

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PAI-1 transcriptional regulation during the G0 --> G1 transition in human epidermal keratinocytes

28 September 2017

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TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling

28 September 2017

1 reference

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Upstream stimulating factors: highly versatile stress-responsive transcription factors.

28 September 2017

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Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells

28 September 2017

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Upstream stimulatory factor regulates E box-dependent PAI-1 transcription in human epidermal keratinocytes

28 September 2017

1 reference

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Convergence of p53 and TGF-beta signaling networks.

28 September 2017

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Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma

28 September 2017

1 reference

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Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy

28 September 2017

1 reference

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Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1.

28 September 2017

1 reference

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ECM homeostasis in renal diseases: a genomic approach.

28 September 2017

1 reference

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Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction

28 September 2017

1 reference

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Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.

28 September 2017

1 reference

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Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

28 September 2017

1 reference

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Targets of transcriptional regulation by transforming growth factor-beta: expression profile analysis using oligonucleotide arrays

28 September 2017

1 reference

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Growth state-dependent regulation of plasminogen activator inhibitor type-1 gene expression during epithelial cell stimulation by serum and transforming growth factor-beta1.

28 September 2017

1 reference

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The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

28 September 2017

1 reference

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Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove

28 September 2017

1 reference

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PAI-1: An Integrator of Cell Signaling and Migration

28 September 2017

1 reference

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Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?

31 May 2018

1 reference

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Kidney fibrosis in hypertensive rats: role of oxidative stress

31 May 2018

1 reference

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Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor beta response

31 May 2018

1 reference

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p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine

31 May 2018

1 reference

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The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein

31 May 2018

1 reference

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Suppression of Par-4 protects human renal proximal tubule cells from apoptosis induced by oxidative stress.

31 May 2018

1 reference

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Delayed Treatment with Plasminogen Activator Inhibitor-1 Decoys Reduces Tubulointerstitial Fibrosis

28 November 2018

1 reference

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Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells.

28 November 2018

1 reference

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Serine proteases, inhibitors and receptors in renal fibrosis.

28 November 2018

1 reference

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Integration of non-SMAD and SMAD signaling in TGF-beta1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells.

28 November 2018

1 reference

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Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension

28 November 2018

1 reference

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Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508263

TGF-beta1 siRNA suppresses the tubulointerstitial fibrosis in the kidney of ureteral obstruction

28 November 2018

1 reference

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Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice.

28 November 2018

1 reference

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Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.

28 November 2018

1 reference

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Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent

28 November 2018

1 reference

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Characterization of an animal model of spontaneous congenital unilateral obstructive uropathy by cDNA microarray analysis

28 November 2018

1 reference

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Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction.

28 November 2018

1 reference

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DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508263

PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508263

Transforming growth factor-beta 1 stimulates angiotensinogen gene expression in kidney proximal tubular cells

28 November 2018

1 reference

12 December 2020

Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice

1 reference

12 December 2020

1 reference

12 December 2020

Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury

1 reference

12 December 2020

High glucose upregulates upstream stimulatory factor 2 in human renal proximal tubular cells through angiotensin II-dependent activation of CREB.

1 reference

12 December 2020

10.1016/J.CELLSIG.2012.10.003

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

23063463

1 reference