Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence (Q34196515)

31 July 2017

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence (English)

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31 July 2017

Serpin family E member 1

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GOA release 2020-03-11

replicative senescence

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GOA release 2020-03-11

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René Bernards

3

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author name string

Roderik M Kortlever

series ordinal

1

1 reference

PubMed ID

16862142

31 July 2017

Paul J Higgins

series ordinal

2

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31 July 2017

23 July 2006

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31 July 2017

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31 July 2017

8

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31 July 2017

877-884

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31 July 2017

8

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https://scigraph.springernature.com/pub.10.1038/ncb1448

31 July 2017

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cites work

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Friends or foes - bipolar effects of the tumour stroma in cancer

5 July 2018

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Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice

5 July 2018

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Human cancer, PTEN and the PI-3 kinase pathway

5 July 2018

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

5 July 2018

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Urokinase plasminogen activator system: a multifunctional role in tumor progression and metastasis.

5 July 2018

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PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

5 July 2018

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Simultaneous inhibition of GSK3alpha and GSK3beta using hairpin siRNA expression vectors.

5 July 2018

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Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

5 July 2018

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The RB and p53 pathways in cancer

5 July 2018

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E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

5 July 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

5 July 2018

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Plasminogen activators in vascular remodeling and angiogenesis

5 July 2018

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Reactive stroma in prostate cancer progression

5 July 2018

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

5 July 2018

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

5 July 2018

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Genes involved in senescence and immortalization

5 July 2018

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The plasminogen activation system in tumor growth, invasion, and metastasis

5 July 2018

1 reference

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Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

5 July 2018

1 reference

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

5 July 2018

1 reference

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Tissue structure, nuclear organization, and gene expression in normal and malignant breast

5 July 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

5 July 2018

1 reference

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954492

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

1 reference

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

5 July 2018

1 reference

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Cloning and characterization of murine p16INK4a and p15INK4b genes

5 July 2018

1 reference

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Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors.

5 July 2018

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

5 July 2018

1 reference

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Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53

5 July 2018

1 reference

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The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954492

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

5 July 2018

1 reference

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Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells

28 October 2018

1 reference

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Stable suppression of tumorigenicity by virus-mediated RNA interference

28 October 2018

1 reference

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Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.

28 October 2018

1 reference

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Tumor surveillance via the ARF-p53 pathway.

28 October 2018

1 reference

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Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954492

Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression

28 October 2018

1 reference

12 December 2020

Urokinase-type and tissue-type plasminogen activators as growth factors of human fibroblasts

1 reference

12 December 2020

Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts

1 reference

12 December 2020

Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue

1 reference

12 December 2020

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCB1448

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCB1448

1 reference

PubMed ID

16862142

Dimensions Publication ID

31 July 2017

0 references

1 reference

31 July 2017

1 reference

PubMed ID

16862142