Galectin-3: its role in asthma and potential as an anti-inflammatory target (Q27023534)

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2 March 2020

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19 July 2021

Galectin-3: its role in asthma and potential as an anti-inflammatory target (English)

1 reference

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2 March 2020

2 references

4 August 2019

14 December 2019

0 references

1 reference

4 August 2019

1 reference

14 December 2019

anti-inflammatory agent

1 reference

19 July 2021

4

1 reference

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2 March 2020

author name string

Peng Gao

series ordinal

1

2 references

Crossref

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2 March 2020

Jodie L Simpson

series ordinal

2

2 references

Crossref

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24313993%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Jie Zhang

series ordinal

3

2 references

Crossref

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2 March 2020

language of work or name

1 reference

9 December 2013

5 references

4 August 2019

14 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24313993%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

19 July 2021

5 references

4 August 2019

14 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24313993%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

19 July 2021

14

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2 March 2020

page(s)

136

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Creative Commons Attribution 2.0 Generic

2 March 2020

copyright license

3 references

4 August 2019

14 December 2019

https://scigraph.springernature.com/pub.10.1186/1465-9921-14-136

19 July 2021

0 references

0 references

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Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation

28 September 2017

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Mepolizumab and exacerbations of refractory eosinophilic asthma

28 September 2017

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Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis

28 September 2017

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Galectin-3 but not galectin-1 induces mast cell death by oxidative stress and mitochondrial permeability transition

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity

28 September 2017

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28 September 2017

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28 September 2017

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Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses

28 September 2017

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Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma

28 September 2017

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28 September 2017

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Galectin-3, a novel binding partner of beta-catenin

28 September 2017

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28 September 2017

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Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity

28 September 2017

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Seeing strangers or announcing "danger": galectin-3 in two models of innate immunity

28 September 2017

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Introduction to galectins

28 September 2017

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Critical role of galectin-3 in phagocytosis by macrophages

28 September 2017

1 reference

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Nuclear localization of Galectin-3 in transformed thyroid cells: a role in transcriptional regulation

28 September 2017

1 reference

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Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro.

28 September 2017

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Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions

28 September 2017

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Galectinomics: finding themes in complexity

28 September 2017

1 reference

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An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells

28 September 2017

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Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?

28 September 2017

1 reference

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Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia

28 September 2017

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Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis: implication of galectin-3 function during metastasis

28 September 2017

1 reference

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Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytes

28 September 2017

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28 September 2017

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Galectins: a new family of regulators of inflammation

28 September 2017

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Concentrations of galectin-3 in the sera of normal controls and cancer patients

28 September 2017

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Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.

28 September 2017

1 reference

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God must love galectins; he made so many of them

28 September 2017

1 reference

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Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy

28 September 2017

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C-type lectins and galectins mediate innate and adaptive immune functions: their roles in the complement activation pathway

28 September 2017

1 reference

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Immunologic basis of antigen-induced airway hyperresponsiveness

28 September 2017

1 reference

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Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells

28 September 2017

1 reference

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Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages.

28 September 2017

1 reference

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Gene expression profiling in lungs of chronic asthmatic mice treated with galectin-3: downregulation of inflammatory and regulatory genes

28 September 2017

1 reference

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Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.

31 May 2018

1 reference

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Galectin 3 and its binding protein in rheumatoid arthritis.

31 May 2018

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Induction of cell death in T lymphocytes by invasin via beta1-integrin

31 May 2018

1 reference

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Activation of rat basophilic leukemia cells by epsilon BP, an IgE-binding endogenous lectin

31 May 2018

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IgE-binding protein. Subcellular location and gene expression in many murine tissues and cells

31 May 2018

1 reference

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Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

31 May 2018

1 reference

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Reduced expression of galectin-1 and galectin-9 by leucocytes in asthma patients.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

28 November 2018

1 reference

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Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

CD66b regulates adhesion and activation of human eosinophils.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Serum galectin-3 and galectin-3 binding protein levels in Behçet's disease and their association with disease activity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma.

28 November 2018

1 reference

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Role of galectin-3 in prion infections of the CNS.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Crosslinking of CD66B on peripheral blood neutrophils mediates the release of interleukin-8 from intracellular storage.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Gene therapy with galectin-3 inhibits bronchial obstruction and inflammation in antigen-challenged rats through interleukin-5 gene downregulation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878924

Visualization of galectin-3 oligomerization on the surface of neutrophils and endothelial cells using fluorescence resonance energy transfer

28 November 2018

1 reference

12 December 2020

Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies

1 reference

12 December 2020

A human lectin, galectin-3 (epsilon bp/Mac-2), stimulates superoxide production by neutrophils

1 reference

12 December 2020

Galectin-3 promotes adhesion of human neutrophils to laminin

1 reference

12 December 2020

CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway

1 reference

12 December 2020

Embryonic implantation in galectin 1/galectin 3 double mutant mice

1 reference

12 December 2020

Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice

1 reference

12 December 2020

Inflammatory subtypes in asthma: assessment and identification using induced sputum

1 reference

12 December 2020

Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3

1 reference

12 December 2020

Role of galectin-3 in leukocyte recruitment in a murine model of lung infection by Streptococcus pneumoniae

1 reference

12 December 2020

Serum level of galectin-3 in human bladder cancer

1 reference

12 December 2020

Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients

1 reference

12 December 2020

A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma

1 reference

12 December 2020

Elevated production of galectin-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progression

1 reference

12 December 2020

Identifiers

DOI

10.1186/1465-9921-14-136

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24313993%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 March 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1465-9921-14-136

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24313993%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24313993%20AND%20SRC:MED&resulttype=core&format=json