Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents (Q27305419)

25 June 2017

title

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents (English)

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Colleen M Niswender

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Craig W Lindsley

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P Jeffrey Conn

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ORCID Public Data File 2021

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Karen J. Gregory

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Karen J Gregory

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Michael Bubser

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Zixiu Xiang

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Nellie Byun

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Michael T Nedelcovych

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Michael T Nedelcovych

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Shaun R Stauffer

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Hilde Lavreysen

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Claire Mackie

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Susana Conde-Ceide

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José M Bartolomé-Nebreda

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object named as

José M Bartolomé-Nebreda

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Thomas Steckler

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Carrie K Jones

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Jerri M Rook

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Xiaohui Lv

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Ayan Ghoshal

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Jonathan W Dickerson

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Thomas M Bridges

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Kari A Johnson

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Daniel J Foster

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Paige N Vinson

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Analisa D Thompson

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Rebekah L Collier

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Robert W Gould

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J Scott Daniels

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Jesus Alcazar

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Gregor J Macdonald

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John C Talpos

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25 June 2017

language of work or name

English

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publication date

30 April 2015

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25 June 2017

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volume

86

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25 June 2017

issue

4

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25 June 2017

page(s)

1029-1040

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A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization

25 June 2017

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In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.

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The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

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Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

28 September 2017

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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

28 September 2017

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

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28 September 2017

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28 September 2017

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Protein kinase C modulation of NMDA currents: an important link for LTP induction

28 September 2017

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Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes

28 September 2017

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Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents

31 May 2018

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31 May 2018

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Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices.

31 May 2018

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28 November 2018

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28 November 2018

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Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target

28 November 2018

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The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat.

28 November 2018

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28 November 2018

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The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats

28 November 2018

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Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release

28 November 2018

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28 November 2018

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Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices.

28 November 2018

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The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

28 November 2018

1 reference

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Differential regulation of metabotropic glutamate receptor 5-mediated phosphoinositide hydrolysis and extracellular signal-regulated kinase responses by protein kinase C in cultured astrocytes

28 November 2018

1 reference

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Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.

28 November 2018

1 reference

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Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus

28 November 2018

1 reference

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Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

28 November 2018

1 reference

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(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25937172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2015.03.063

1 reference

25 June 2017

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