Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex (Q27313360)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25275521%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex (English)

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20 February 2020

7

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20 February 2020

8

Nathaniel Heintz

1 reference

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20 February 2020

10

Zhenyu Yue

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20 February 2020

author name string

Nicole C McKnight

1

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20 February 2020

Yun Zhong

2

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20 February 2020

Mitchell S Wold

3

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20 February 2020

Shiaoching Gong

4

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20 February 2020

Greg R Phillips

5

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20 February 2020

Zhixun Dou

6

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20 February 2020

Wei-Xing Zong

9

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20 February 2020

language of work or name

English

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publication date

2 October 2014

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20 February 2020

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20 February 2020

volume

10

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20 February 2020

issue

10

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20 February 2020

page(s)

e1004626

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Creative Commons Attribution 4.0 International

20 February 2020

copyright license

start time

2 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs

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PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

21 March 2017

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Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism

21 March 2017

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Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking

21 March 2017

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Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

21 March 2017

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Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

21 March 2017

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Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

21 March 2017

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A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic

21 March 2017

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Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

21 March 2017

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

21 March 2017

1 reference

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

21 March 2017

1 reference

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A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

21 March 2017

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 March 2017

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Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

21 March 2017

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EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

21 March 2017

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Autophagy fights disease through cellular self-digestion

21 March 2017

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Autophagy in the Pathogenesis of Disease

21 March 2017

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Rab GTPases as coordinators of vesicle traffic

21 March 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 March 2017

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 March 2017

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A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice

21 March 2017

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21 March 2017

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

28 September 2017

1 reference

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Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

21 March 2017

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FYVE fingers bind PtdIns(3)P

21 March 2017

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Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

21 March 2017

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Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

21 March 2017

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

21 March 2017

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Induction of autophagy in axonal dystrophy and degeneration

21 March 2017

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

21 March 2017

1 reference

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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

21 March 2017

1 reference

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WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.

7 April 2017

1 reference

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Beclin 1, an Essential Component and Master Regulator of PI3K-III in Health and Disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Beclin1: a role in membrane dynamics and beyond

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

From a global view to focused examination: understanding cellular function of lipid kinase VPS34-Beclin 1 complex in autophagy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Monitoring autophagy in lysosomal storage disorders

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

A simple silver-gold intensification procedure for double DAB labeling studies in electron microscopy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4183436

Closed head injury induces upregulation of Beclin 1 at the cortical site of injury.

31 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004626

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004626

Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004626

Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004626

Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25275521

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1004626

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25275521%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25275521%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25275521%20AND%20SRC:MED&resulttype=core&format=json