TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes (Q27322386)

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English	TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes	scientific article

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scholarly article

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TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes (English)

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toll-like receptor

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object named as

Paul F McKay

1

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object named as

Darrick Carter

5

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6

object named as

Robin J Shattock

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2

object named as

Deborah F L King

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3

object named as

Jamie F S Mann

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author name string

Guillermo Barinaga

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language of work or name

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publication date

2016

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11

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2

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e0148984

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copyright license

Creative Commons Attribution 4.0 International

10 February 2016

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April 2022 Public Data File from Crossref

copyright status

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TLR cross-talk confers specificity to innate immunity

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Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant

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Intranasal administration of a therapeutic HIV vaccine (Vacc-4x) induces dose-dependent systemic and mucosal immune responses in a randomized controlled trial

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A comparative review of toll-like receptor 4 expression and functionality in different animal species

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Minipigs as an animal model for dermal vaccine delivery

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Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes

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Mucosal application of gp140 encoding DNA polyplexes to different tissues results in altered immunological outcomes in mice.

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The pig: a model for human infectious diseases

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Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations

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TLR accessory molecules

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The porcine dendritic cell family

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The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

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Mucosal immunity and vaccines

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CL097, a TLR7/8 ligand, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression.

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Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.

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Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.

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21 January 2018

Effects of adjuvants on the immune response of pigs after intradermal administration of antigen

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Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod

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High-affinity IgA needs TH17 cell functional plasticity

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histological and ultrastructural examinations of porcine tonsils

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12 December 2020

based on heuristic

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Parenteral and mucosal prime-boost immunization strategies in mice with hepatitis B surface antigen and CpG DNA

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https://pubmed.ncbi.nlm.nih.gov/26862758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0148984

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2016PLoSO..1148984M

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