Visualizing Vpr-induced G2 arrest and apoptosis (Q27329545)

April 2022 Public Data File from Crossref

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Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest

1 reference

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Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

21 March 2017

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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

21 March 2017

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HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

21 March 2017

1 reference

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Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis

21 March 2017

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The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

21 March 2017

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HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator

21 March 2017

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Viral protein R regulates nuclear import of the HIV-1 pre-integration complex

21 March 2017

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The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

21 March 2017

1 reference

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Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

21 March 2017

1 reference

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Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.

28 September 2017

1 reference

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Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication

28 September 2017

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HIV-1 Vif promotes the G₁- to S-phase cell-cycle transition

28 September 2017

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Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells

28 September 2017

1 reference

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HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr).

28 September 2017

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HIV-1 Vpr: a novel role in regulating RNA splicing

28 September 2017

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HIV-1 Vpr: regulator of viral survival

28 September 2017

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Role of Vpr in HIV-1 nuclear import: therapeutic implications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Novel nuclear import of Vpr promoted by importin alpha is crucial for human immunodeficiency virus type 1 replication in macrophages.

28 September 2017

1 reference

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HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT

28 September 2017

1 reference

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Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.

28 September 2017

1 reference

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The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest

28 September 2017

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A novel role for Vpr of human immunodeficiency virus type 1 as a regulator of the splicing of cellular pre-mRNA.

28 September 2017

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Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.

28 September 2017

1 reference

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Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

28 September 2017

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Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.

28 September 2017

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Evidence for a cytopathogenicity determinant in HIV-1 Vpr.

28 September 2017

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Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr.

28 September 2017

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Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes.

28 September 2017

1 reference

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Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer

28 September 2017

1 reference

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Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

28 September 2017

1 reference

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Induction of M-phase arrest and apoptosis after HIV-1 Vpr expression through uncoupling of nuclear and centrosomal cycle in HeLa cells.

28 September 2017

1 reference

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A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G(1) cell cycle arrest

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo

28 September 2017

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HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.

28 September 2017

1 reference

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Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Vpr-induced cell cycle arrest is conserved among primate lentiviruses.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency

28 September 2017

1 reference

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Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Human immunodeficiency virus type 1 Vpr induces cell cycle arrest at the G(1) phase and apoptosis via disruption of mitochondrial function in rodent cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Micronuclei formation and aneuploidy induced by Vpr, an accessory gene of human immunodeficiency virus type 1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Human immunodeficiency virus type 1 Vpr gene product prevents cell proliferation on mouse NIH3T3 cells without the G2 arrest of the cell cycle

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3899331

Importin-alpha promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086840

Human immunodeficiency virus type 1 Vpr interacts with spliceosomal protein SAP145 to mediate cellular pre-mRNA splicing inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086840

Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G(2) arrest of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086840

A high-throughput method for development of FRET-based indicators for proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0086840

Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24466265

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T Cell Apoptosis Causes Peripheral T Cell Depletion in Mice Transgenic for the HIV-1 vpr Gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24466265

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0086840

1 reference

3451929

ADS bibcode

2014PLoSO...986840M

0 references

3451929

1 reference

1 reference

1 reference