Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition (Q27335920)

25 June 2017

title

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition (English)

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25 June 2017

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ChEBI release 2020-05-28

12

Raymond F Schinazi

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25 June 2017

8

Tamara R McBrayer

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25 June 2017

4

Franck Amblard

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25 June 2017

5

Hongwang Zhang

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25 June 2017

6

Longhu Zhou

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25 June 2017

7

Junxing Shi

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25 June 2017

James H Nettles

1

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25 June 2017

Richard A Stanton

2

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25 June 2017

Joshua Broyde

3

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25 June 2017

Tony Whitaker

9

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25 June 2017

Steven J Coats

10

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25 June 2017

James J Kohler

11

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25 June 2017

language of work or name

English

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publication date

3 November 2014

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Journal of Medicinal Chemistry

25 June 2017

published in

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25 June 2017

volume

57

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25 June 2017

issue

23

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25 June 2017

page(s)

10031-10043

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The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

25 June 2017

cites work

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Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

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21 March 2017

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7 April 2017

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Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication

7 April 2017

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Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

29 September 2017

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Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

29 September 2017

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Discovery of daclatasvir, a pan-genotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect

29 September 2017

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Approaches to hepatitis C treatment and cure using NS5A inhibitors

29 September 2017

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Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

29 September 2017

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The hepatitis C virus NS5A inhibitor daclatasvir has a dual mode of action and leads to a new virus half-life estimate

29 September 2017

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The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

29 September 2017

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29 September 2017

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29 September 2017

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Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

29 September 2017

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Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir.

29 September 2017

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The C terminus of NS5A domain II is a key determinant of hepatitis C virus genome replication, but is not required for virion assembly and release

29 September 2017

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Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension

29 September 2017

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Synthesis and evaluation of novel potent HCV NS5A inhibitors

29 September 2017

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Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors

29 September 2017

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Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action

29 September 2017

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

29 September 2017

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29 September 2017

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Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules

29 September 2017

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The NS5A protein of hepatitis C virus is a zinc metalloprotein

29 September 2017

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Hepatitis C virus NS5A: tales of a promiscuous protein

29 September 2017

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Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.

29 September 2017

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Alamethicin helices in a bilayer and in solution: molecular dynamics simulations

29 September 2017

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A Refined Model of the HCV NS5A protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Discovery and development of hepatitis C virus NS5A replication complex inhibitors

2 June 2018

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Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir

2 June 2018

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Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Characterizations of HCV NS5A replication complex inhibitors.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Characterization of Hepatitis C virus resistance from a multiple-dose clinical trial of the novel NS5A inhibitor GS-5885.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics

2 June 2018

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Recent progress in understanding activity cliffs and their utility in medicinal chemistry.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266333

Flexible 3D pharmacophores as descriptors of dynamic biological space.

27 November 2018

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27 November 2018

Identifiers

DOI

10.1021/JM501291C

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25 June 2017

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