The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection (Q38113079)

29 August 2017

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection (English)

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29 August 2017

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29 August 2017

Ralf Bartenschlager

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author name string

Francois Penin

series ordinal

3

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PubMed ID

23748342

29 August 2017

language of work or name

English

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publication date

10 June 2013

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Nature Reviews Microbiology

29 August 2017

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29 August 2017

11

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29 August 2017

7

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29 August 2017

482-496

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https://scigraph.springernature.com/pub.10.1038/nrmicro3046

29 August 2017

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Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus

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The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity

21 January 2018

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

21 January 2018

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Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

21 January 2018

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Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action

21 January 2018

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

21 January 2018

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21 January 2018

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

21 January 2018

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Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication

21 January 2018

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Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis

21 January 2018

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Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

21 January 2018

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

21 January 2018

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Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs

21 January 2018

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Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase

21 January 2018

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In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance

21 January 2018

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Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase

21 January 2018

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Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

21 January 2018

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Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus

21 January 2018

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Sofosbuvir for previously untreated chronic hepatitis C infection

21 January 2018

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Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.

21 January 2018

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Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options

21 January 2018

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Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B.

21 January 2018

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Antiviral strategies in hepatitis C virus infection

21 January 2018

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Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase

21 January 2018

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

21 January 2018

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Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir

21 January 2018

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Exploratory study of oral combination antiviral therapy for hepatitis C.

21 January 2018

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Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796

21 January 2018

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Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase

21 January 2018

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The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function

21 January 2018

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Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

21 January 2018

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Palmitoylation and Polymerization of Hepatitis C Virus NS4B Protein

21 January 2018

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Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B

21 January 2018

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Dual topology of the processed hepatitis C virus protein NS4B is influenced by the NS5A protein.

21 January 2018

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Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B

21 January 2018

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NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes

21 January 2018

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Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis

21 January 2018

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Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity.

21 January 2018

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The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus

21 January 2018

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The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without Ha-ras co-transfection

21 January 2018

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Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B.

21 January 2018

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Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

21 January 2018

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Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy

21 January 2018

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The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy

21 January 2018

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The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels

21 January 2018

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Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production

21 January 2018

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Direct-acting and host-targeting HCV inhibitors: current and future directions

21 January 2018

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Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals

21 January 2018

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Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes

21 January 2018

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Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

21 January 2018

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DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

21 January 2018

1 reference

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Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

21 January 2018

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Update on alisporivir in treatment of viral hepatitis C.

21 January 2018

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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

21 January 2018

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Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome

21 January 2018

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Hepatitis C virus RNA translation

21 January 2018

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Cellular cofactors affecting hepatitis C virus infection and replication

21 January 2018

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Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex.

21 January 2018

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Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.

21 January 2018

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microRNA-122 stimulates translation of hepatitis C virus RNA

21 January 2018

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

21 January 2018

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Treatment of HCV infection by targeting microRNA

21 January 2018

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MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

21 January 2018

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Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.

21 January 2018

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

21 January 2018

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Telaprevir for retreatment of HCV infection

21 January 2018

1 reference

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Telaprevir for previously untreated chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3046

Boceprevir for untreated chronic HCV genotype 1 infection

21 January 2018

1 reference

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Boceprevir for previously treated chronic HCV genotype 1 infection

21 January 2018

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Preliminary study of two antiviral agents for hepatitis C genotype 1.

21 January 2018

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Efficient initiation of HCV RNA replication in cell culture

21 January 2018

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Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

21 January 2018

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Hepatitis C virus replicons: potential role for drug development

21 January 2018

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Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

21 January 2018

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Replication of hepatitis C virus genotype 3a in cultured cells

21 January 2018

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Development of robust hepatitis C virus genotype 4 subgenomic replicons

21 January 2018

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Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

21 January 2018

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Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes

21 January 2018

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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

21 January 2018

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Recent advances in hepatitis C virus cell entry

21 January 2018

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Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon

21 January 2018

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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

21 January 2018

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Complete replication of hepatitis C virus in cell culture

21 January 2018

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Robust hepatitis C virus infection in vitro

21 January 2018

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Cell culture systems for hepatitis C virus.

21 January 2018

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Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells

21 January 2018

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Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3046

Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3046

HCV and HCC: clinical update and a review of HCC-associated viral mutations in the core gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3046

Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3046

Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3046

New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3046

Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23748342

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

JUMP-C: a randomized trial of mericitabine plus pegylated interferon alpha-2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23748342

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23748342

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRMICRO3046

1 reference

PubMed ID

23748342

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23748342