Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A (Q27489369)

1

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John M Robida

2

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Sreedhar Chinnaswamy

3

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Guanghui Yi

4

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Jason M Robotham

5

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Heather B Nelson

6

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Andre Irsigler

7

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C Cheng Kao

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

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language of work or name

English

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publication date

July 2009

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published in

Hepatology

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volume

50

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issue

1

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page(s)

25-33

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cites work

1 reference

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Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

20 March 2017

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Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro

20 March 2017

1 reference

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Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression

20 March 2017

1 reference

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Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

20 March 2017

1 reference

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Robust hepatitis C virus infection in vitro

20 March 2017

1 reference

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Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins

20 March 2017

1 reference

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Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals

20 March 2017

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Selection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase

20 March 2017

1 reference

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Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727352

RNA motifs that determine specificity between a viral replicase and its promoter

20 March 2017

1 reference

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De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase

20 March 2017

1 reference

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20 March 2017

1 reference

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

20 March 2017

1 reference

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

20 March 2017

1 reference

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

20 March 2017

1 reference

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Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.

7 April 2017

1 reference

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Cell culture and infection system for hepatitis C virus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727352

Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation: effects on virus replication and recurrent hepatitis

29 September 2017

1 reference

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Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins

29 September 2017

1 reference

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Specific inhibition of hepatitis C virus replication by cyclosporin A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727352

Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727352

Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2727352

Factors regulating template switch in vitro by viral RNA-dependent RNA polymerases: implications for RNA-RNA recombination

29 September 2017

1 reference

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Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

29 September 2017

1 reference

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Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo

2 June 2018

1 reference

Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation.

21 January 2018

1 reference

Hepatitis C virus viral load after conversion from tacrolimus to cyclosporine in liver transplant patients: a pilot study.

21 January 2018

1 reference

Impact of tacrolimus versus cyclosporine in hepatitis C virus-infected liver transplant recipients on recurrent hepatitis: a prospective, randomized trial

21 January 2018

1 reference

A cyclosporine-based immunosuppressive regimen may be better than tacrolimus for long-term liver allograft survival in recipients transplanted for hepatitis C.

21 January 2018

1 reference

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

21 January 2018

1 reference

Crystallization and preliminary X-ray crystallographic studies on the bacteriophage Φ6 RNA-dependent RNA polymerase

21 January 2018

1 reference

Combined interferon alpha2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial

21 January 2018

1 reference

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