Chromatin-modulating protein MRC1 YCL061C (Q27548476)

6 references

8 April 2019

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Defining the budding yeast chromatin-associated interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

molecular function

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

ND

cell component

nuclear replication fork

1 reference

8 April 2019

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

replication fork protection complex

1 reference

8 April 2019

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

nuclear chromosome

1 reference

14 February 2019

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

nuclear periphery

1 reference

8 April 2019

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

telomere

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

IEA

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25588&geneProductId=UniProtKB:P25588

1 reference

5 June 2018

IEA

biological process

DNA repair

Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

replication fork protection

Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

maintenance of DNA repeat elements

1 reference

8 April 2019

Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

mitotic intra-S DNA damage checkpoint signaling

1 reference

8 April 2019

Mrc1 transduces signals of DNA replication stress to activate Rad53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

regulation of nuclear cell cycle DNA replication

1 reference

8 April 2019

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

mitotic sister chromatid cohesion

telomere maintenance

1 reference

8 April 2019

Mrc1, a non-essential DNA replication protein, is required for telomere end protection following loss of capping by Cdc13, Yku or telomerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

DNA replication checkpoint signaling

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

14 February 2019

Mrc1 transduces signals of DNA replication stress to activate Rad53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

14 February 2019

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

DNA replication checkpoint signaling

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

8 April 2019

Mrc1 transduces signals of DNA replication stress to activate Rad53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

silent mating-type cassette heterochromatin assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25588

DNA replication checkpoint mediator, MRC1 domain

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25588

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference