Bifunctional endoribonuclease/protein kinase IRE1 YHR079C (Q27552011)

Protein kinase-like domain superfamily

1 reference

WD40/YVTN repeat-like-containing domain superfamily

1 reference

KEN domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

KEN domain, protein family

1 reference

PUB domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Pyrrolo-quinoline quinone beta-propeller repeat, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

protein homodimerization activity

1 reference

9 May 2019

An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

endoribonuclease activity

1 reference

7 November 2018

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32361&geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

ribonuclease activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32361&geneProductId=UniProtKB:P32361

protein kinase activity

1 reference

7 November 2018

1 reference

9 May 2019

Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

identical protein binding

IPI

3 references

9 May 2019

The unfolded protein response signals through high-order assembly of Ire1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

protein serine/threonine kinase activity

IPI

protein kinase activity

3 references

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

unfolded protein binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

integral component of membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

integral component of endoplasmic reticulum membrane

IDA

1 reference

9 May 2019

A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32361&geneProductId=UniProtKB:P32361

IDA

endoplasmic reticulum

1 reference

7 November 2018

endoplasmic reticulum membrane

IRE1-TRAF2-ASK1 complex

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

inositol metabolic process

1 reference

9 May 2019

IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

protein homooligomerization

1 reference

9 May 2019

The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

response to unfolded protein

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32361&geneProductId=UniProtKB:P32361

fungal-type cell wall organization

3 references

9 May 2019

The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

endoplasmic reticulum unfolded protein response

IGI

response to endoplasmic reticulum stress

1 reference

9 May 2019

Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

protein trans-autophosphorylation

1 reference

9 May 2019

The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

regulation of transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32361&geneProductId=UniProtKB:P32361

RNA phosphodiester bond hydrolysis

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

RNA phosphodiester bond hydrolysis, endonucleolytic

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

protein localization to Golgi apparatus

1 reference

9 May 2019

Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

protein phosphorylation

3 references

9 May 2019

9 May 2019

The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

Global analysis of protein phosphorylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

endoplasmic reticulum unfolded protein response

HDA

3 references

9 May 2019

A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

IRE1-mediated unfolded protein response

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32361

has part(s)

protein kinase domain

1 reference

Pyrrolo-quinoline quinone beta-propeller repeat

1 reference

PUB domain

1 reference

KEN domain

1 reference

serine/threonine-protein kinase, active site

1 reference