Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D (Q27617260)

2

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D Moore

3

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L J DeLucas

4

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J E Volanakis

5

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S V Narayana

Structure of alpha-lytic protease complexed with its pro region

6

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language of work or name

English

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publication date

15 February 1999

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published in

The EMBO Journal

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volume

18

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issue

4

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page(s)

804-14

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cites work

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Structure of 3,4-dichloroisocoumarin-inhibited factor D

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Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity

20 March 2017

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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

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Complement factor D, a novel serine protease

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Structure of human factor D. A complement system protein at 2.0 A resolution

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Crystal structure of bovine procarboxypeptidase A-S6 subunit III, a highly structured truncated zymogen E

20 March 2017

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The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C

20 March 2017

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Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation

20 March 2017

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Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation

20 March 2017

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Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution

20 March 2017

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Structure of alpha-chymotrypsin refined at 1.68 A resolution

20 March 2017

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The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis

20 March 2017

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The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

20 March 2017

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Three-dimensional structure of porcine procarboxypeptidase B: a structural basis of its inactivity

20 March 2017

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Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type)

20 March 2017

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Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue

20 March 2017

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Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin

20 March 2017

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Structure of bovine trypsinogen at 1.9 Å resolution

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Errors in protein structures

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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Stereochemical quality of protein structure coordinates

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Use of non-crystallographic symmetry in protein structure refinement

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Mechanism of action of factor D of the alternative complement pathway

20 March 2017

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Checking your imagination: applications of the free R value

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Structural basis of substrate specificity in the serine proteases

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Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function

29 September 2017

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The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding

29 September 2017

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Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases

29 September 2017

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The role of pro regions in protein folding.

29 September 2017

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Evolution of Proteolytic Enzymes

29 September 2017

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Three-dimensional structure of porcine pancreatic procarboxypeptidase A. A comparison of the A and B zymogens and their determinants for inhibition and activation.

29 September 2017

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Crystal structure of bovine trypsinogen at 1-8 A resolution. I. Data collection, application of patterson search techniques and preliminary structural interpretation

29 September 2017

1 reference

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The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

29 September 2017

1 reference

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Mechanisms of zymogen activation

29 September 2017

1 reference

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Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

29 September 2017

1 reference

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The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

2 June 2018

1 reference

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Improvement of macromolecular electron-density maps by the simultaneous application of real and reciprocal space constraints.

2 June 2018

1 reference

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Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation 1 1Edited by I. A. Wilson

27 November 2018

1 reference

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Crystal structure analysis and refinement of two variants of trigonal trypsinogen: trigonal trypsin and PEG (polyethylene glycol) trypsinogen and their comparison with orthorhombic trypsin and trigonal trypsinogen

27 November 2018

1 reference

12 December 2020

Structure of diisopropyl fluorophosphate-inhibited factor D

1 reference

12 December 2020

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution

1 reference

12 December 2020

Preliminary crystallographic studies on human complement pro-factor D

1 reference

12 December 2020

Recombinant and native zymogen forms of human complement factor D

1 reference

12 December 2020

release_hqrminf2nzb7re527gwmt2ypna

Identifiers

DOI

10.1093/EMBOJ/18.4.804

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hqrminf2nzb7re527gwmt2ypna

24 November 2022