(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase (Q27622497)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10805774%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase (English)

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6 November 2019

9

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6 November 2019

4

J Stürzebecher

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6 November 2019

author name string

S Sperl

1

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6 November 2019

U Jacob

2

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6 November 2019

N Arroyo de Prada

3

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6 November 2019

O G Wilhelm

5

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6 November 2019

W Bode

6

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6 November 2019

V Magdolen

7

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6 November 2019

R Huber

8

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6 November 2019

language of work or name

English

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publication date

1 May 2000

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6 November 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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6 November 2019

volume

97

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6 November 2019

issue

10

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6 November 2019

page(s)

5113-5118

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The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

6 November 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

The crystal structure of the catalytic domain of human urokinase-type plasminogen activator

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Structure of human des(1-45) factor Xa at 2.2 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Geometry of binding of the N alpha-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin. X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Raster3D Version 2.0. A program for photorealistic molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

20 March 2017

https://api.crossref.org/works/10.1073/PNAS.97.10.5113

Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

3-Amidinophenylalanine-based inhibitors of urokinase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Natural and synthetic inhibitors of the tumor-associated serine protease urokinase-type plasminogen activator

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Synthetic inhibitors of thrombin and factor Xa: from bench to bedside

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Inhibitors of urokinase reduce size of prostate cancer xenografts in severe combined immunodeficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Prevention of prostate-cancer metastasis in vivo by a novel synthetic inhibitor of urokinase-type plasminogen activator (uPA).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Proteases and protease inhibitors in tumor progression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

The urokinase-type plasminogen activator system in cancer metastasis: a review

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Aromatic amidines. Comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Amiloride selectively inhibits the urokinase-type plasminogen activator

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Morphological, immunohistochemical and biochemical characterization of 6 newly established human ovarian carcinoma cell lines

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

Synthetic inhibitors of serine proteinases. 17. The effect of benzamidine derivatives on the activity of urokinase and the reduction of fibrinolysis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25790

A graphics model building and refinement system for macromolecules

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Optimal subsite occupancy and design of a selective inhibitor of urokinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Accurate bond and angle parameters for X-ray protein structure refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Effects of synthetic urokinase inhibitors on local invasion and metastasis in a murine mammary tumor model

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Design of benzamidine-type inhibitors of factor Xa

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

X-ray analysis of a thrombin inhibitor-trypsin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.10.5113

Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy

21 January 2018

1 reference

12 December 2020

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor

1 reference

12 December 2020

Inhibition of mammary tumor cell adhesion, migration, and invasion by the selective synthetic urokinase inhibitor B428

1 reference

12 December 2020

Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.97.10.5113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10805774%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

0 references

1 reference

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6 November 2019

PubMed publication ID

10805774

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