Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase (Q27625384)

7

object named as

J Janin

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author name string

P Meyer

1

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B Schneider

2

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S Sarfati

3

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D Deville-Bonne

4

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C Guerreiro

5

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J Boretto

6

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M Véron

Catalytic mechanism of nucleoside diphosphate kinase investigated using nucleotide analogues, viscosity effects, and X-ray crystallography

8

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language of work or name

English

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publication date

17 July 2000

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published in

The EMBO Journal

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volume

19

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issue

14

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page(s)

3520-9

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cites work

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Nucleophilic activation by positioning in phosphoryl transfer catalyzed by nucleoside diphosphate kinase

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

20 March 2017

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Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

20 March 2017

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X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase

20 March 2017

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AlF3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

20 March 2017

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X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution

20 March 2017

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X-ray structure of nucleoside diphosphate kinase complexed with thymidine diphosphate and Mg2+ at 2-A resolution

20 March 2017

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The crystal structure of a human nucleoside diphosphate kinase, NM23-H2

20 March 2017

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3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

20 March 2017

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X-ray structure of nucleoside diphosphate kinase

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

20 March 2017

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

20 March 2017

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Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate

20 March 2017

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Mechanism and fidelity of HIV reverse transcriptase

20 March 2017

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HIV-1 drug resistance in newly infected individuals

20 March 2017

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Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.

29 September 2017

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Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy

29 September 2017

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Synthesis of 5-substituted 2'-deoxycytidine 5'-(alpha-P-borano)triphosphates, their incorporationinto DNA and effects on exonuclease

29 September 2017

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

29 September 2017

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Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer

29 September 2017

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In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

29 September 2017

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Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

29 September 2017

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Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.

29 September 2017

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The occurrence of C-H...O hydrogen bonds in proteins

29 September 2017

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Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates

29 September 2017

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Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus

29 September 2017

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A role for CH...O interactions in protein-DNA recognition

29 September 2017

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Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase

2 June 2018

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The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro

2 June 2018

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A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors

2 June 2018

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Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine

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The motif D loop of human immunodeficiency virus type 1 reverse transcriptase is critical for nucleoside 5'-triphosphate selectivity

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Processing of X-ray diffraction data collected in oscillation mode

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Structural Studies of a Borane-Modified Phosphate Diester Linkage: Ab Initio Calculations on the Dimethylboranophosphate Anion and the Single-Crystal X-ray Structure of Its Diisopropylammonium Salt

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The mechanism of phosphorylation of anti-HIV D4T by nucleoside diphosphate kinase

21 January 2018

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The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase

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Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase

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