Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor (Q27640358)

1

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Alexander A Fedorov

2

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Seung-Yub Lee

3

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Xiao-Ling Guo

4

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Kui Shen

5

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David S Lawrence

6

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Zhong-Yin Zhang

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

4 April 2003

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published in

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volume

278

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issue

14

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page(s)

12406-14

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cites work

Protein tyrosine phosphatases in signal transduction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Protein tyrosine phosphatases: prospects for therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

PTP1B regulates leptin signal transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Substrate specificity of the protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Crystal structure of human protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

[Difluro(phosphono)methyl]phenylalanine-containing peptide inhibitors of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Comparative kinetic analysis and substrate specificity of the tandem catalytic domains of the receptor-like protein-tyrosine phosphatase alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Assessment of protein-tyrosine phosphatase 1B substrate specificity using "inverse alanine scanning"

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Potent Inhibition of Insulin Receptor Dephosphorylation by a Hexamer Peptide Containing the Phosphotyrosyl Mimetic F2Pmp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

Potent non-peptidyl inhibitors of protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212491200

21 January 2018

Identifiers

DOI

10.1074/JBC.M212491200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12547827

1 reference

Consolidated OpenCitations Corpus – April 2017