Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor (Q27641040)

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2 November 2019

title

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor (English)

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2 November 2019

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5

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2 November 2019

author name string

Shiqing Li

1

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2 November 2019

Nicole D Covino

2

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2 November 2019

Evan G Stein

3

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2 November 2019

Jeffrey H Till

4

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2 November 2019

language of work or name

English

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publication date

21 April 2003

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Journal of Biological Chemistry

2 November 2019

published in

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2 November 2019

volume

278

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2 November 2019

issue

28

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2 November 2019

page(s)

26007-26014

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

2 November 2019

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The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals

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Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

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Stat5 is a physiological substrate of the insulin receptor

21 January 2018

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Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites

21 January 2018

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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Processing of X-ray diffraction data collected in oscillation mode

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Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism

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21 January 2018

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Insulin receptor tyrosine kinase domain auto-dephosphorylation

21 January 2018

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Cis-autophosphorylation of juxtamembrane tyrosines in the insulin receptor kinase domain

21 January 2018

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Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor

21 January 2018

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Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain

21 January 2018

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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

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21 January 2018

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

21 January 2018

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

21 January 2018

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Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

21 January 2018

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21 January 2018

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A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo

21 January 2018

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Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M302425200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12707268%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference