Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct (Q27641298)

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Structure, function, and biogenesis of glycosomes in kinetoplastida

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei : The glycosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

The glycosomes of the Kinetoplastida

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Glycolysis in Trypanosoma brucei

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Compartmentation of carbohydrate metabolism in trypanosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Metabolic compartmentation in African trypanosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Molecular characterization of glycosomal NAD(+)-dependent glycerol 3-phosphate dehydrogenase from Trypanosoma brucei rhodesiense.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Glycolysis as a target for the design of new anti-trypanosome drugs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Cloning and characterization of the NAD-linked glycerol-3-phosphate dehydrogenases of Trypanosoma brucei brucei and Leishmania mexicana mexicana and expression of the trypanosome enzyme in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

inferred from DOI database lookup

7 January 2021

based on heuristic

Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

What Controls Glycolysis in Bloodstream FormTrypanosoma brucei?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Synthesis and activity of inhibitors highly specific for the glycolytic enzymes from Trypanosoma brucei

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

A comparative study of Leishmania mexicana amastigotes and promastigotes, enzyme activities and subcellular locations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme, NADH-dependent fumarate reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Comparative study of Leishmania mexicana and Trypanosoma brucei NAD-dependent glycerol-3-phosphate dehydrogenase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Conformation of Polypeptides and Proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

NADP-dependent enzymes. I: Conserved stereochemistry of cofactor binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Insights into the mechanism of domain closure and substrate specificity of glutamate dehydrogenase from Clostridium symbiosum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Coenzyme-induced conformational changes in glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

The CCP4 suite: programs for protein crystallography

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Mapping the protein universe

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Lysine 183 is the general base in the 6-phosphogluconate dehydrogenase-catalyzed reaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Kinetic study of the catalytic mechanism of mannitol dehydrogenase from Pseudomonas fluorescens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

A catalytic consensus motif for D-mannitol 2-dehydrogenase, a member of a polyol-specific long-chain dehydrogenase family, revealed by kinetic characterization of site-directed mutants of the enzyme from Pseudomonas fluorescens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Examining the relative timing of hydrogen abstraction steps during NAD(+)-dependent oxidation of secondary alcohols catalyzed by long-chain D-mannitol dehydrogenase from Pseudomonas fluorescens using pH and kinetic isotope effects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

QXP: powerful, rapid computer algorithms for structure-based drug design.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Identification of active site residues in E. coli ketopantoate reductase by mutagenesis and chemical rescue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Processing of X-ray diffraction data collected in oscillation mode

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

AMoRe: an automated package for molecular replacement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Refinement of macromolecular structures by the maximum-likelihood method

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

PROCHECK: a program to check the stereochemical quality of protein structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Raster3D: photorealistic molecular graphics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900421-2