Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation (Q27642932)

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English	Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation	scientific article

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scholarly article

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Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation (English)

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crystal structure

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3

object named as

Mike G Tennant

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author name string

Kathleen Aertgeerts

1

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Sheng Ye

2

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Michelle L Kraus

4

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Joe Rogers

5

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Bi-Ching Sang

6

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Robert J Skene

7

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David R Webb

8

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G Sridhar Prasad

9

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publication date

February 2004

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Protein Science

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13

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2

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412-21

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Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV

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20 March 2017

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine

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20 March 2017

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

20 March 2017

The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold

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20 March 2017

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII

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20 March 2017

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

20 March 2017

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

20 March 2017

Catalysis of serine oligopeptidases is controlled by a gating filter mechanism

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20 March 2017

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis

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20 March 2017

Raster3D: photorealistic molecular graphics

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20 March 2017

The CCP4 suite: programs for protein crystallography

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20 March 2017

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

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20 March 2017

Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family

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20 March 2017

Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family

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20 March 2017

Alpha/beta hydrolase fold enzymes: the family keeps growing

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

20 March 2017

Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

A fully integrated protein crystallization platform for small-molecule drug discovery

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

Automation of the collection and processing of X-ray diffraction data -- a generic approach

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29 September 2017

Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

Autonomic regulation of islet hormone secretion--implications for health and disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs

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29 September 2017

Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

CD26, let it cut or cut it down.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

Dipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review).

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

G protein heterodimers: new structures propel new questions

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

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A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

Mapping the active site of papain with the aid of peptide substrates and inhibitors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

29 September 2017

The structure and function of CD26 in the T-cell immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

2 June 2018

Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

2 June 2018

Structure of CD26 (dipeptidyl peptidase IV) and function in human T cell activation.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

2 June 2018

Triggering of the proteinase dipeptidyl peptidase IV (CD26) amplifies human T lymphocyte proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

2 June 2018

Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

2 June 2018

N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

27 November 2018

The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

27 November 2018

Ab initio QM/MM dynamics simulation of the tetrahedral intermediate of serine proteases: insights into the active site hydrogen-bonding network

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

27 November 2018

Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

27 November 2018

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases

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27 November 2018

Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

27 November 2018

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2286704

27 November 2018

Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two highly conserved glutamic acid residues in the predicted β propeller domain of dipeptidyl peptidase IV are required for its enzyme activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of dipeptidyl peptidase activity in serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of dipeptidyl peptidase IV proteolysis of growth hormone-releasing factor and analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of dipeptidyl peptidase IV (CD26) from human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV from human serum: purification, characterization, and N-terminal amino acid sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/14718659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1110/PS.03460604

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Consolidated OpenCitations Corpus – April 2017

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PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

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