Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy (Q27643106)

1

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Bjarke E Hansen

Bjarke E Hansen

2

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Lars Fugger

10

Lars Fugger

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Jack L. Strominger

8

Jack L Strominger

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Yvonne Jones

9

E Yvonne Jones

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author name string

Jessica R Wyer

3

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Robert E Esnouf

5

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Arne Svejgaard

6

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John I Bell

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

17 February 2004

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published in

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volume

101

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issue

7

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page(s)

1999-2004

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cites work

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The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

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Errors in protein structures

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Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.

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HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

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DQ (rather than DR) gene marks susceptibility to narcolepsy

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HLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy

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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

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Expression of recombinant HLA-DR2 molecules. Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR alpha beta heterodimers.

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A peptide binding motif for HLA-DQA1*0102/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus.

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

27 November 2018

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12 December 2020

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12 December 2020

Narcolepsy and immunity

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12 December 2020

Insulin-dependent diabetes mellitus

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12 December 2020

Limited loss of tolerance to islet autoantigens in ICA+ first degree relatives of patients with type I diabetes expressing the HLA dqb1*0602 allele

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12 December 2020

Antiislet autoantibodies usually develop sequentially rather than simultaneously

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12 December 2020