Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels (Q27643216)

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22 December 2019

title

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels (English)

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22 December 2019

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1

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22 December 2019

Frank Bosmans

3

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22 December 2019

Frank Bosmans

4

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22 December 2019

Elba Villegas

6

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22 December 2019

7

Jan Tytgat

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22 December 2019

8

Raymond S Norton

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22 December 2019

author name string

Jennifer K Sabo

2

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22 December 2019

Bert Billen

5

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22 December 2019

language of work or name

English

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publication date

5 December 2006

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Journal of Biological Chemistry

22 December 2019

number of pages

10

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based on heuristic

inferred from page(s)

published in

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22 December 2019

volume

282

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22 December 2019

issue

7

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22 December 2019

page(s)

4643-4652

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From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

22 December 2019

cites work

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A new approach to insect-pest control--combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity.

21 January 2018

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Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

21 January 2018

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Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

21 January 2018

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Localization of the receptor site for alpha-scorpion toxins by antibody mapping: implications for sodium channel topology

21 January 2018

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Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

21 January 2018

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Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel

21 January 2018

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Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels.

21 January 2018

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Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.

21 January 2018

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Effects of Tityus serrulatus scorpion toxin gamma on voltage-gated Na+ channels.

21 January 2018

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Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

21 January 2018

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Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative "hot spot" common to all scorpion beta-toxins affecting Na+ channels.

21 January 2018

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Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels.

21 January 2018

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The putative bioactive surface of insect-selective scorpion excitatory neurotoxins.

21 January 2018

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Role of lysine and tryptophan residues in the biological activity of toxin VII (Ts gamma) from the scorpion Tityus serrulatus.

21 January 2018

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Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels

21 January 2018

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Purification and characterization of raventoxin-I and raventoxin-III, two neurotoxic peptides from the venom of the spider Macrothele raveni

21 January 2018

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Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

21 January 2018

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Peptide self-association in aqueous trifluoroethanol monitored by pulsed field gradient NMR diffusion measurements.

21 January 2018

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The program XEASY for computer-supported NMR spectral analysis of biological macromolecules

21 January 2018

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Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA

21 January 2018

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The Xplor-NIH NMR molecular structure determination package

21 January 2018

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21 January 2018

The Protein Data Bank

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Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel

21 January 2018

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Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function

21 January 2018

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Existence of distinct sodium channel messenger RNAs in rat brain

21 January 2018

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Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

21 January 2018

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Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue

21 January 2018

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A relational database for sequence-specific protein NMR data

21 January 2018

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A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides

21 January 2018

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Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues.

21 January 2018

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Refined solution structure of omega-conotoxin GVIA: implications for calcium channel binding

21 January 2018

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Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA

21 January 2018

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Solution structure of Ptu1, a toxin from the assassin bug Peirates turpis that blocks the voltage-sensitive calcium channel N-type

21 January 2018

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Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge

21 January 2018

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Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.

21 January 2018

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Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxin

21 January 2018

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NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position.

21 January 2018

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'Random coil' 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M605403200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17148449%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

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