Crystal structure of theStreptococcus pneumoniaemevalonate kinase in complex with diphosphomevalonate (Q27644306)

2

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Matthew W Vetting

3

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Steven L Roderick

4

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Thomas S Leyh

Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis

5

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publication date

May 2007

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published in

Protein Science

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volume

16

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issue

5

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page(s)

983-9

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cites work

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Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome

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Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man

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29 September 2017

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Identification of a mutation cluster in mevalonate kinase deficiency, including a new mutation in a patient of Mennonite ancestry.

29 September 2017

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Identification and functional characterization of an active-site lysine in mevalonate kinase

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Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target

2 June 2018

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Molecular functions of conserved aspects of the GHMP kinase family

27 November 2018

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The kinetic mechanism of phosphomevalonate kinase.

27 November 2018

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Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease

27 November 2018

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Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17400916