A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Q27644391)

10 September 2018

1 reference

24 September 2018

1 reference

15 December 2018

1 reference

19 December 2018

1 reference

20 December 2018

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20 December 2018

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Iñigo Angulo-Barturen

25

0 references

Maria Belen Jimenez-Diaz

Maria Lafuente-Monasterio

23

0 references

19

0 references

Clemens Kocken

31

0 references

Santiago Ferrer Bazaga

24

0 references

Maria Santos Martinez

22

0 references

Andrea Ruecker

Andrea Ruecker

38

0 references

Diana R. Tomchick

Diana R Tomchick

11

0 references

Vicky M. Avery

Vicky M Avery

34

0 references

Susan A. Charman

Susan A Charman

53

0 references

David A. Fidock

David A Fidock

17

0 references

Michael Delves

Michael Delves

36

0 references

Sandra Duffy

Sandra Duffy

35

0 references

Robert Sauerwein

32

Robert Sauerwein

0 references

Sergio Wittlin

18

Sergio Wittlin

0 references

Jeremy Burrows

52

Jeremy N Burrows

0 references

Jon C. Mirsalis

44

Jon Mirsalis

0 references

Margaret A. Phillips

1

Margaret A Phillips

0 references

Pradipsinh K. Rathod

51

Pradipsinh K Rathod

0 references

Farah El Mazouni

8

Farah El Mazouni

0 references

Didier Leroy

49

Didier Leroy

0 references

Julie Lotharius

2

Julie Lotharius

0 references

Kennan Marsh

3

Kennan Marsh

0 references

Karen White

6

Karen L White

0 references

Sreekanth Kokkonda

10

Francisco Javier Gamo Benito

Sreekanth Kokkonda

0 references

20

Francisco Javier Gamo Benito

0 references

Koen J Dechering

33

Koen Dechering

0 references

Hemangi Sharma

42

Lalitha Iyer

0 references

Thomas Rueckle

46

Thomas Rueckle

0 references

Robert E Sinden

37

Robert Sinden

0 references

author name string

Anthony Dayan

5

0 references

Jacqueline W Njoroge

7

0 references

Yanbin Lao

9

0 references

Xiaoyi Deng

12

0 references

Trevor Laird

13

0 references

Sangeeta N Bhatia

14

0 references

Sandra March

15

0 references

Caroline L Ng

16

0 references

Laura Maria Sanz Alonso

21

0 references

John N Haselden

26

0 references

James Louttit

27

0 references

Yi Cui

28

0 references

Arun Sridhar

29

0 references

Anna-Marie Zeeman

30

0 references

Kristina S Wickham

39

0 references

Rosemary Rochford

40

0 references

Janet Gahagen

41

0 references

Ed Riccio

43

0 references

Ian Bathhurst

45

0 references

Xavier Ding

47

0 references

Brice Campo

48

0 references

M John Rogers

50

0 references

John White

Science Translational Medicine

4

0 references

language of work or name

English

0 references

publication date

15 July 2015

0 references

published in

0 references

volume

7

0 references

issue

296

0 references

page(s)

296ra111

0 references

cites work

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In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

20 March 2017

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20 March 2017

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Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

20 March 2017

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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

20 March 2017

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Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

20 March 2017

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Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes

20 March 2017

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Identification of an antimalarial synthetic trioxolane drug development candidate

20 March 2017

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Features and development of Coot

20 March 2017

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Solving structures of protein complexes by molecular replacement with Phaser

20 March 2017

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P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action

20 March 2017

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The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

20 March 2017

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Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

20 March 2017

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Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications

20 March 2017

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An introduction to data reduction: space-group determination, scaling and intensity statistics

20 March 2017

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A novel multiple-stage antimalarial agent that inhibits protein synthesis

7 April 2017

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(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

24 May 2017

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A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers

29 September 2017

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Spiroindolone KAE609 for falciparum and vivax malaria

29 September 2017

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KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

29 September 2017

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Novel inhibitors of the Plasmodium falciparum electron transport chain

29 September 2017

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KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

29 September 2017

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Single-dose radical cure of Plasmodium vivax: a step closer

29 September 2017

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In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

29 September 2017

1 reference

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Identification of inhibitors of Plasmodium falciparum gametocyte development

29 September 2017

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Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity

29 September 2017

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29 September 2017

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Safety evaluation of leflunomide in rheumatoid arthritis

29 September 2017

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Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs

29 September 2017

1 reference

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The changing epidemiology of malaria elimination: new strategies for new challenges

29 September 2017

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Quinolone-3-diarylethers: a new class of antimalarial drug.

29 September 2017

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Malaria biology and disease pathogenesis: insights for new treatments

29 September 2017

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The global pipeline of new medicines for the control and elimination of malaria

29 September 2017

1 reference

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A framework for assessing the risk of resistance for anti-malarials in development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

On the relationship among QT interval, atrial fibrillation, and torsade de pointes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Role of the breast cancer resistance protein (ABCG2) in drug transport

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

The bacterial tryptophan reverse mutation assay with Escherichia coli WP2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

The Ames Salmonella/microsome mutagenicity assay

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Optimal dose finding for novel antimalarial combination therapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

2 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA6645

Towards real-time monitoring of artemisinin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA6645

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA6645

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA6645

A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA6645

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA6645

Apricot extract inhibits the P-gp-mediated efflux of talinolol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAA6645

The history of the editorship of Teratology during the period from July 1, 1976 to January 1, 1993.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4539048

When should QT be measured? Summer solstice or Christmas Eve?

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26180101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The use of C(av) rather than AUC in safety assessment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26180101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26180101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAA6645

1 reference

198385

198385

1 reference

1 reference

1 reference