Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. (Q37057973)

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scientific article published on 04 June 2008

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English	Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.	scientific article published on 04 June 2008

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scholarly article

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8 January 2020

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum (English)

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8 January 2020

Plasmodium falciparum

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Nicholas A Malmquist

3

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8 January 2020

Margaret A. Phillips

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Margaret A Phillips

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8 January 2020

Pradipsinh K. Rathod

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Pradipsinh K Rathod

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8 January 2020

Farah El Mazouni

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Farah El Mazouni

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8 January 2020

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Ramesh Gujjar

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8 January 2020

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Jeffrey Baldwin

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8 January 2020

John White

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4 June 2008

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8 January 2020

Journal of Medicinal Chemistry

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8 January 2020

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8 January 2020

3649-3653

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8 January 2020

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

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Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

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High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

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Drug-like properties and the causes of poor solubility and poor permeability

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Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase

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Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

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Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro

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Purines and pyrimidines in malarial parasites.

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Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts

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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

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Biochemistry of Plasmodium (malarial parasites)

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Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

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Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18522386

12 December 2020

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10.1021/JM8001026

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8 January 2020

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8 January 2020

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8 January 2020

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