Structural Analysis of a Glutathione Transferase A1-1 Mutant Tailored for High Catalytic Efficiency with Toxic Alkenals (Q27646550)

1

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Isolde Le Trong

2

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Kimberly A Kripps

3

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Ronald E Stenkamp

5

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Bengt Mannervik

6

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William M Atkins

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

7

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language of work or name

English

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publication date

18 August 2009

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published in

Biochemistry

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volume

48

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issue

32

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page(s)

7698-704

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cites work

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Localization of the C-terminus of rat glutathione S-transferase A1-1: crystal structure of mutants W21F and W21F/F220Y

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Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface

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Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

20 March 2017

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Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4

20 March 2017

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Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

20 March 2017

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Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate

20 March 2017

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Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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20 March 2017

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Contribution of aromatic-aromatic interactions to the anomalous pK(a) of tyrosine-9 and the C-terminal dynamics of glutathione S-transferase A1-1

20 March 2017

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The C-terminus of glutathione S-transferase A1-1 is required for entropically-driven ligand binding

20 March 2017

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The catalytic Tyr-9 of glutathione S-transferase A1-1 controls the dynamics of the C terminus

20 March 2017

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Glutathione transferases

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Aromatic-aromatic interaction: a mechanism of protein structure stabilization

7 April 2017

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Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase

7 April 2017

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The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases

29 September 2017

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New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix

29 September 2017

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The anomalous pKa of Tyr-9 in glutathione S-transferase A1-1 catalyzes product release

29 September 2017

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Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation

29 September 2017

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Structure, catalytic mechanism, and evolution of the glutathione transferases

29 September 2017

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The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site

29 September 2017

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Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases

29 September 2017

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Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

27 November 2018

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A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases.

27 November 2018

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Glutathione induces helical formation in the carboxy terminus of human glutathione transferase A1-1.

27 November 2018

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Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions.

27 November 2018

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The C-terminal region of human glutathione transferase A1-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9.

27 November 2018

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Stopped-flow kinetic analysis of the ligand-induced coil-helix transition in glutathione S-transferase A1-1: evidence for a persistent denatured state

27 November 2018

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12 December 2020

Role of the C-terminal helix 9 in the stability and ligandin function of class alpha glutathione transferase A1-1

1 reference

12 December 2020

Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020