Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases (Q57447557)

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31 December 2019

title

Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases (English)

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31 December 2019

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author name string

Liming Hou

1

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31 December 2019

Matthew T Honaker

2

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Laura M Shireman

3

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31 December 2019

Larissa M Balogh

4

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Arthur G Roberts

5

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Kei-Cheuk Ng

6

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William M Atkins

8

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language of work or name

English

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publication date

8 June 2007

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Journal of Biological Chemistry

31 December 2019

published in

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31 December 2019

volume

282

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issue

32

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page(s)

23264-23274

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Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways.

31 December 2019

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Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis

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Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis

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Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily

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Enzymes with extra talents: moonlighting functions and catalytic promiscuity

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Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

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Natural history as a predictor of protein evolvability

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Catalytic promiscuity and the divergent evolution of DNA repair enzymes

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Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis.

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Cross-reactivity and conformational multiplicity of an anti-polycyclic aromatic hydrocarbon mAb

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Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain

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Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics

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Protein dynamics and the immunological evolution of molecular recognition.

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Flexibility and molecular recognition in the immune system.

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

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Promiscuity: what protects us, perplexes us.

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Glutathione transferases

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Small molecule approach to studying protein tyrosine phosphatase

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Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides

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Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

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Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation

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Local protein dynamics and catalysis: detection of segmental motion associated with rate-limiting product release by a glutathione transferase

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Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases

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The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress

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The role of glutathione in the isomerization of delta 5-androstene-3,17-dione catalyzed by human glutathione transferase A1-1.

21 January 2018

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Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase

21 January 2018

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Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases

21 January 2018

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Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M700868200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17561509%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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