Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate † (Q27649183)

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English	Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate †	scientific article

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scholarly article

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28 December 2019

Caught in the Act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate (English)

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28 December 2019

crystal structure

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Andrey Kovalevsky

1

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28 December 2019

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Irene T Weber

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28 December 2019

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Alexander A Chumanevich

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28 December 2019

Fengling Liu

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28 December 2019

John M Louis

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4 December 2007

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28 December 2019

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28 December 2019

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28 December 2019

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28 December 2019

14854-14864

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28 December 2019

Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy

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Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes

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Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

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Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: Insights into the mechanisms of drug resistance

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How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease

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20 March 2017

X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes

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Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

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20 March 2017

Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.

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20 March 2017

Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates

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29 September 2017

Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity

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Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate

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29 September 2017

Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

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Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.

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Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases

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The Low-Barrier Double-Well Potential of the O(δ)(1)-H-O(δ)(1) Hydrogen Bond in Unbound HIV Protease: A QM/MM Characterization

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inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

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A combined quantum/classical molecular dynamics study of the catalytic mechanism of HIV protease

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10.1021/BI700822G

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release_i5me5oiixzcwbodkrkiduqd5ju

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24 November 2022

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mapped directly with Wikidata item

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28 December 2019

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28 December 2019

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