Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. (Q34462935)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16480273%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M (English)

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16 January 2020

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ChEBI release 2020-05-28

1

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16 January 2020

9

Irene T Weber

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16 January 2020

author name string

Yunfeng Tie

2

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16 January 2020

Fengling Liu

3

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16 January 2020

Peter I Boross

4

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16 January 2020

Yuan-Fang Wang

5

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16 January 2020

Sofiya Leshchenko

6

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16 January 2020

Arun K Ghosh

7

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Robert W Harrison

8

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language of work or name

English

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publication date

1 February 2006

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Journal of Medicinal Chemistry

16 January 2020

published in

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volume

49

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issue

4

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16 January 2020

page(s)

1379-1387

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SHELXL: high-resolution refinement

16 January 2020

cites work

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TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates

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Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor

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Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

6 July 2018

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Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: Insights into the mechanisms of drug resistance

6 July 2018

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Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

6 July 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16480273

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16480273

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM050943C

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16480273%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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16 January 2020

PubMed publication ID

16480273

1 reference