Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation (Q27649728)

1

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Joseph Yanchunas

2

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Carolyn Weigelt

3

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Kevin Kish

4

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Herbert E Klei

5

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Dianlin Xie

6

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Yaqun Zhang

7

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Martin Corbett

8

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James K Tamura

9

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Bin He

10

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Lawrence G Hamann

11

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Mark S Kirby

12

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Jovita Marcinkeviciene

One site mutation disrupts dimer formation in human DPP-IV proteins

13

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publication date

February 2008

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published in

Protein Science

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volume

17

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issue

2

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page(s)

240-50

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cites work

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Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation

20 March 2017

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High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine

20 March 2017

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Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

20 March 2017

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20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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On the size of the active site in proteases. I. Papain

20 March 2017

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Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family

20 March 2017

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Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

20 March 2017

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High-density miniaturized thermal shift assays as a general strategy for drug discovery

20 March 2017

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Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).

7 April 2017

1 reference

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Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year

29 September 2017

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Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology

29 September 2017

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Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes

29 September 2017

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Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin

29 September 2017

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A new concept for the mechanism of action of chymotrypsin: the role of the low-barrier hydrogen bond

29 September 2017

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AMoRe: an automated package for molecular replacement

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1110%2FPS.073253208

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

21 January 2018

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Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV.

27 November 2018

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1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties

27 November 2018

1 reference

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Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

27 November 2018

1 reference

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NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV

27 November 2018

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

High resolution nuclear magnetic resonance study of the histidine—Aspartate hydrogen bond in chymotrypsin and chymotrypsinogen

1 reference

12 December 2020

Low barrier hydrogen bond is absent in the catalytic triads in the ground state but Is present in a transition-state complex in the prolyl oligopeptidase family of serine proteases

1 reference

12 December 2020

Identifiers

DOI

10.1110/PS.073253208

1 reference

1 reference

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PubMed publication ID

18227430

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