Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies (Q27649971)

5

Margaret A Phillips

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Frederick S Buckner

2

Frederick S Buckner

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Nicholas A Malmquist

Nicholas A Malmquist

4

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Wim G J Hol

11

Wim G J Hol

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author name string

Tracy L Arakaki

1

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J Robert Gillespie

3

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Oleksandr Kalyuzhniy

6

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Joseph R Luft

7

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George T Detitta

8

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Christophe L M J Verlinde

9

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Ethan A Merritt

Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis

12

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language of work or name

English

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publication date

April 2008

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published in

Molecular Microbiology

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volume

68

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issue

1

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page(s)

37-50

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cites work

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Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

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Purification and characterization of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallization and preliminary X-ray diffraction studies of the enzyme

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Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate

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The B form of dihydroorotate dehydrogenase from Lactococcus lactis consists of two different subunits, encoded by the pyrDb and pyrK genes, and contains FMN, FAD, and [FeS] redox centers.

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Identification of the first pyrimidine nucleobase transporter in Leishmania: similarities with the Trypanosoma brucei U1 transporter and antileishmanial activity of uracil analogues.

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Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi

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21 January 2018

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Trypanosoma brucei: A survey of pyrimidine transport activities

21 January 2018

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Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18312275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18312275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18312275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1365-2958.2008.06131.X

1 reference

1 reference

1 reference

PubMed publication ID

18312275

1 reference