Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase (Q27651307)

2

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author name string

Katja Gotthardt

1

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Arjan Kortholt

3

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Peter J M Van Haastert

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

4

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language of work or name

English

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publication date

20 August 2008

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published in

The EMBO Journal

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volume

27

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issue

16

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page(s)

2239-49

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cites work

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

20 March 2017

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

20 March 2017

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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A common LRRK2 mutation in idiopathic Parkinson's disease

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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29 September 2017

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29 September 2017

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LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain

29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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27 November 2018

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Structural insights into HypB, a GTP-binding protein that regulates metal binding

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18650931

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18650931

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.150

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2008.150

1 reference

1 reference

1 reference

PubMed publication ID

18650931

1 reference