Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation (Q27652517)

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Yu Chen

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Ping Zhang

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Philip D Jeffrey

Structural mechanism of demethylation and inactivation of protein phosphatase 2A

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language of work or name

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26 September 2008

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published in

Molecular Cell

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volume

31

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issue

6

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page(s)

873-85

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cites work

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The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation

20 March 2017

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Structural Basis of PP2A Inhibition by Small t Antigen

20 March 2017

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Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

20 March 2017

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Structure of the protein phosphatase 2A holoenzyme

20 March 2017

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Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

20 March 2017

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Structure and mechanism of the phosphotyrosyl phosphatase activator

20 March 2017

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

20 March 2017

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Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

20 March 2017

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Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

20 March 2017

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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

20 March 2017

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Carboxymethylation of nuclear protein serine/threonine phosphatase X

20 March 2017

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The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

20 March 2017

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Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens

20 March 2017

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Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

20 March 2017

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Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein

20 March 2017

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Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus

20 March 2017

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A protein factor essential for microtubule assembly

20 March 2017

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Likelihood-enhanced fast translation functions

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

20 March 2017

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Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p

20 March 2017

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alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

20 March 2017

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Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

20 March 2017

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PP2A: unveiling a reluctant tumor suppressor

7 April 2017

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Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).

29 September 2017

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Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

29 September 2017

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A century of Alzheimer's disease

29 September 2017

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A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers

29 September 2017

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PP2A: the expected tumor suppressor

29 September 2017

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Post-translational modifications of tau protein in Alzheimer's disease

29 September 2017

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Protein phosphatase 2A: variety of forms and diversity of functions

29 September 2017

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Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.

29 September 2017

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Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen

29 September 2017

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Protein phosphatase 2A: a panoply of enzymes.

29 September 2017

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Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit

29 September 2017

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

29 September 2017

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Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

29 September 2017

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29 September 2017

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Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

27 November 2018

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Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818795

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

29 September 2017

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Tubulin requires tau for growth onto microtubule initiating sites

29 September 2017

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Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

29 September 2017

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Production of selenomethionyl-derivatized proteins in baculovirus-infected insect cells

29 September 2017

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The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.

2 June 2018

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The 1.1-angstrom structure of the spindle checkpoint protein Bub3p reveals functional regions.

27 November 2018

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Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

27 November 2018

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Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

27 November 2018

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

27 November 2018

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Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies

27 November 2018

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Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity

27 November 2018

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12 December 2020

Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase

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12 December 2020

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

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12 December 2020

10.1016/J.MOLCEL.2008.08.006

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

18922469

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