Structural Analysis of Spiro β-Lactone Proteasome Inhibitors (Q27652533)

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Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

20 March 2017

1 reference

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Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors

20 March 2017

1 reference

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20S proteasome and its inhibitors: crystallographic knowledge for drug development

29 September 2017

1 reference

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

29 September 2017

1 reference

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Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding

29 September 2017

1 reference

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Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation

29 September 2017

1 reference

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Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome

29 September 2017

1 reference

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Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach

29 September 2017

1 reference

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Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

29 September 2017

1 reference

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Proteasome inhibitors: from research tools to drug candidates

29 September 2017

1 reference

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Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

29 September 2017

1 reference

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Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

29 September 2017

1 reference

12 December 2020

Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates

1 reference

12 December 2020

Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells

1 reference

12 December 2020

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells

1 reference

12 December 2020

Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor

1 reference

12 December 2020