Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure (Q27652622)

GOA release 2020-03-11

Rho family GTPase 3

1 reference

GOA release 2020-03-11

1 reference

1

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Anne Ridley

4

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author name string

Ritu Garg

2

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Paul T C Wan

3

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David Barford

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

5

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language of work or name

English

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publication date

3 December 2008

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published in

The EMBO Journal

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volume

27

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issue

23

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page(s)

3175-85

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cites work

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RhoE binds to ROCK I and inhibits downstream signaling

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Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

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The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

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RhoE function is regulated by ROCK I-mediated phosphorylation

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

29 September 2017

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Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

2 June 2018

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N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization

21 January 2018

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Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil

21 January 2018

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Activation segment exchange: a common mechanism of kinase autophosphorylation?

21 January 2018

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ROCK1 phosphorylates and activates zipper-interacting protein kinase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18946488

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2008.226

1 reference

release_wjlz42c2wbfrrkes5uminda4iy

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

18946488

1 reference