Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl (Q27656389)

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Language	Label	Description	Also known as
English	Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl	scientific article

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scholarly article

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Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl (English)

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Toxoplasma gondii

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Vern Carruthers

9

object named as

Vern B Carruthers

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object named as

Eric T Larson

1

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7

object named as

Matthew Bogyo

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My Hang V. Huynh

3

object named as

My-Hang Huynh

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author name string

Fabiola Parussini

2

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Jonathan D Giebel

4

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Angela M Kelley

5

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Li Zhang

6

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Ethan A Merritt

8

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language of work or name

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publication date

25 September 2009

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full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785372

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21 March 2022

Journal of Biological Chemistry

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284

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39

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26839-50

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2785372/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Exploring inhibitor binding at the S' subsites of cathepsin L

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20 March 2017

Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease

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20 March 2017

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785372

20 March 2017

The Protein Data Bank

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20 March 2017

Crystal structure of human cathepsin K complexed with a potent inhibitor

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20 March 2017

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785372

20 March 2017

Clustal W and Clustal X version 2.0

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20 March 2017

Solving structures of protein complexes by molecular replacement with Phaser

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20 March 2017

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

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20 March 2017

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

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20 March 2017

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

The CCP4 suite: programs for protein crystallography

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20 March 2017

A graphical user interface to the CCP4 program suite

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785372

20 March 2017

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785372

20 March 2017

Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

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20 March 2017

ARP/wARP and molecular replacement

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20 March 2017

Human and mouse proteases: a comparative genomic approach

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20 March 2017

Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80

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20 March 2017

Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

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20 March 2017

An automated system to mount cryo-cooled protein crystals on a synchrotron beam line, using compact sample cassettes and a small-scale robot

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7 April 2017

A deliberate approach to screening for initial crystallization conditions of biological macromolecules

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7 April 2017

Proteases in parasitic diseases

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29 September 2017

ToxoDB: an integrated Toxoplasma gondii database resource

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29 September 2017

A transient forward-targeting element for microneme-regulated secretion in Toxoplasma gondii

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29 September 2017

Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion

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29 September 2017

A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex

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29 September 2017

Pulling together: an integrated model of Toxoplasma cell invasion

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29 September 2017

Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii

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29 September 2017

The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins

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29 September 2017

Cysteine proteases of malaria parasites

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29 September 2017

The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa.

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29 September 2017

Production and activation of recombinant papain-like cysteine proteases

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29 September 2017

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.

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29 September 2017

Lysosomal cysteine proteases (cathepsins): promising drug targets.

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29 September 2017

The lysosomal cysteine proteases

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29 September 2017

Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

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29 September 2017

The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785372

2 June 2018

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

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2 June 2018

QXP: powerful, rapid computer algorithms for structure-based drug design.

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2 June 2018

Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii

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https://api.crossref.org/works/10.1074%2FJBC.M109.003780

21 January 2018

The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing

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https://api.crossref.org/works/10.1074%2FJBC.M109.003780

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

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https://api.crossref.org/works/10.1074%2FJBC.M109.003780

21 January 2018

A solution for the best rotation to relate two sets of vectors

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21 January 2018

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.

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https://api.crossref.org/works/10.1074%2FJBC.M109.003780

21 January 2018

AP-1 in Toxoplasma gondii mediates biogenesis of the rhoptry secretory organelle from a post-Golgi compartment

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https://api.crossref.org/works/10.1074%2FJBC.M109.003780

21 January 2018

The importance of alignment accuracy for molecular replacement.

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27 November 2018

Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.003780

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