Secondary Structure of Huntingtin Amino-Terminal Region (Q27657408)

1

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Yogarany Chelliah

2

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Sang Woo Kim

3

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Ilya Bezprozvanny

The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation

5

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publication date

9 September 2009

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published in

Structure

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volume

17

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issue

9

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page(s)

1205-12

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cites work

1 reference

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Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

20 March 2017

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The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model

20 March 2017

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Molecular origin of polyglutamine aggregation in neurodegenerative diseases

20 March 2017

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

20 March 2017

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20 March 2017

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Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment

29 September 2017

1 reference

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Calcium signaling and neurodegenerative diseases

29 September 2017

1 reference

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Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization

29 September 2017

1 reference

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Polyglutamine neurodegeneration: protein misfolding revisited.

29 September 2017

1 reference

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Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

29 September 2017

1 reference

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Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

29 September 2017

1 reference

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Transcriptional signatures in Huntington's disease

29 September 2017

1 reference

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Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.

29 September 2017

1 reference

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Flanking sequences profoundly alter polyglutamine toxicity in yeast

29 September 2017

1 reference

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Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes

29 September 2017

1 reference

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Characterization of a possible amyloidogenic precursor in glutamine-repeat neurodegenerative diseases

29 September 2017

1 reference

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Conformational constraints for amyloid fibrillation: the importance of being unfolded

29 September 2017

1 reference

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

29 September 2017

1 reference

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From Alzheimer to Huntington: why is a structural understanding so difficult?

29 September 2017

1 reference

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

29 September 2017

1 reference

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A linear lattice model for polyglutamine in CAG-expansion diseases

29 September 2017

1 reference

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Peptide aggregation in neurodegenerative disease

29 September 2017

1 reference

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Amyloid fibers are water-filled nanotubes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Lessons from animal models of Huntington's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

29 September 2017

1 reference

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Huntington's disease: the challenge for cell biologists

29 September 2017

1 reference

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Strategies for macromolecular synchrotron crystallography.

29 September 2017

1 reference

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Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein

29 September 2017

1 reference

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pH-dependent structural transitions of Alzheimer amyloid peptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Random coil conformation for extended polyglutamine stretches in aqueous soluble monomeric peptides.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Polyalanine-based peptides as models for self-associated beta-pleated-sheet complexes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Glutamine repeats and inherited neurodegenerative diseases: molecular aspects

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Pathogenic and Non-pathogenic Polyglutamine Tracts Have Similar Structural Properties: Towards a Length-dependent Toxicity Gradient

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Oligoproline effects on polyglutamine conformation and aggregation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Characterizing the conformational ensemble of monomeric polyglutamine.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Solution structure of polyglutamine tracts in GST-polyglutamine fusion proteins

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Modeling protein homopolymeric repeats: possible polyglutamine structural motifs for Huntington's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Prion protein peptides induce alpha-helix to beta-sheet conformational transitions

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863341

Evidence for polyproline II helical structure in short polyglutamine tracts

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19748341

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A toxic monomeric conformer of the polyglutamine protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19748341

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STR.2009.08.002

1 reference

2331162

2331162

1 reference

1 reference

1 reference