The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State (Q27657797)

19 October 2023

4

Albert Weixlbaumer

Albert

Weixlbaumer

1 reference

19 October 2023

Venkatraman Ramakrishnan

V Ramakrishnan

6

V

Ramakrishnan

1 reference

19 October 2023

5

Ann C Kelley

Ann C

Kelley

1 reference

19 October 2023

Yong-Gui Gao

1

Yong-Gui

Gao

1 reference

19 October 2023

Christine M Dunham

series ordinal

3

author given names

Christine M

author last names

Dunham

1 reference

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

19 October 2023

language of work or name

English

0 references

publication date

30 October 2009

0 references

published in

Science

0 references

volume

326

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issue

5953

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page(s)

694-9

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXα

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Locking and unlocking of ribosomal motions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Recognition of cognate transfer RNA by the 30S ribosomal subunit

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

A detailed view of a ribosomal active site: the structure of the L11-RNA complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Structure of the 70S ribosome complexed with mRNA and tRNA

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Structures of the bacterial ribosome at 3.5 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Ribosome structure and the mechanism of translation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

A ratchet-like inter-subunit reorganization of the ribosome during translocation

20 March 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Thermus thermophilus L11 methyltransferase, PrmA, is dispensable for growth and preferentially modifies free ribosomal protein L11 prior to ribosome assembly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Kinetically competent intermediates in the translocation step of protein synthesis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Control of phosphate release from elongation factor G by ribosomal protein L7/12.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Intermediate states in the movement of transfer RNA in the ribosome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

The antibiotic viomycin traps the ribosome in an intermediate state of translocation.

2 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

Structural insights into fusidic acid resistance and sensitivity in EF-G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

Mutations in the G-domain of elongation factor G from Thermus thermophilus affect both its interaction with GTP and fusidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

GTPase activation of elongation factors Tu and G on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

A Detailed View of a Ribosomal Active Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

Initiation factor IF2, thiostrepton and micrococcin prevent the binding of elongation factor G to the Escherichia coli ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179709

EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3763468

Role of Domains 4 and 5 in Elongation Factor G Functions on the Ribosome

27 November 2018

1 reference

12 December 2020

Domain III of elongation factor G from Thermus thermophilus is essential for induction of GTP hydrolysis on the ribosome

1 reference

12 December 2020

Studies on translocation. IV. The hydrolysis of a single round of guanosine triphosphate in the presence of fusidic acid

1 reference

12 December 2020

An intact conformation at the tip of elongation factor G domain IV is functionally important

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.1179709

1 reference

ADS bibcode

2009Sci...326..694G

0 references

1 reference

1 reference

1 reference