Inhibition of HSP90 with pochoximes: SAR and structure-based insights (Q27657973)

6

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Nicolas Winssinger

object named as

Nicolas Winssinger

8

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Len Neckers

7

object named as

Len Neckers

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author name string

Sofia Barluenga

1

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Jean-Gonzague Fontaine

2

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Cuihua Wang

3

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Kais Aouadi

4

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Ruihong Chen

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers

5

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language of work or name

1 reference

23 November 2009

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published in

ChemBioChem

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volume

10

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issue

17

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page(s)

2753-9

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cites work

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Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

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Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues

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NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

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Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol

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Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases

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Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

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Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors

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Discovery and development of purine-scaffold Hsp90 inhibitors

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Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

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HSP90 and the chaperoning of cancer

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Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

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Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

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Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

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Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

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Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

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Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor

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Intrinsic inhibition of the Hsp90 ATPase activity

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Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms

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The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts

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Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol

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Discovery and development of heat shock protein 90 inhibitors

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BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

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Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

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Discovery and development of pyrazole-scaffold Hsp90 inhibitors

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Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

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Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

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12 December 2020

Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study

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Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

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Targeting Hsp90: small-molecule inhibitors and their clinical development

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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

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Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

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Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands

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Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

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Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?

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Pharmacological prevention of Parkinson disease in Drosophila.

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Identifiers

DOI

10.1002/CBIC.200900494

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

19856365

1 reference

Consolidated OpenCitations Corpus – April 2017