17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration (Q40374915)

19 September 2017

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration (English)

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19 September 2017

2

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19 September 2017

9

Gen Sobue

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19 September 2017

Masahiro Waza

1

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19 September 2017

Masahisa Katsuno

3

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19 September 2017

Makoto Minamiyama

4

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19 September 2017

Chen Sang

5

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19 September 2017

Fumiaki Tanaka

6

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19 September 2017

Akira Inukai

7

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19 September 2017

Manabu Doyu

8

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19 September 2017

language of work or name

English

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publication date

11 September 2005

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19 September 2017

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19 September 2017

11

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19 September 2017

10

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19 September 2017

1088-1095

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https://scigraph.springernature.com/pub.10.1038/nm1298

19 September 2017

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cites work

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Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

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p23, a simple protein with complex activities

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Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

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Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

21 January 2018

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Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

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Effect of geldanamycin on androgen receptor function and stability

21 January 2018

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Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein

21 January 2018

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p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

21 January 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

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Modulation of neurodegeneration by molecular chaperones

21 January 2018

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Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

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Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

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Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

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Chaperones increase association of tau protein with microtubules

21 January 2018

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

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Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

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Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis

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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

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Glutamine repeats and neurodegeneration

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Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene

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Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

21 January 2018

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

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Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

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Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

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Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

21 January 2018

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

21 January 2018

1 reference

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

21 January 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

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X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration

21 January 2018

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

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7 January 2021

Nucleotides and two functional states of hsp90

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7 January 2021

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

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7 January 2021

X-linked recessive bulbospinal neuronopathy. A clinicopathological study

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7 January 2021

Founder effect in spinal and bulbar muscular atrophy (SBMA)

1 reference

7 January 2021

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

1 reference

7 January 2021

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1298

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Dimensions Publication ID

19 September 2017

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