Directed Evolution and Structural Characterization of a Simvastatin Synthase (Q27658016)

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11 February 2020

title

Directed evolution and structural characterization of a simvastatin synthase (English)

1 reference

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11 February 2020

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ChEBI release 2020-05-28

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1

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11 February 2020

Michael R Sawaya

4

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11 February 2020

Todd O. Yeates

8

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11 February 2020

author name string

Xinkai Xie

2

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11 February 2020

Inna Pashkov

3

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11 February 2020

Janel Laidman

5

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11 February 2020

Wenjun Zhang

6

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Ralph Cacho

7

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11 February 2020

Yi Tang

9

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publication date

1 October 2009

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11 February 2020

published in

Chemistry and Biology

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volume

16

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issue

10

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page(s)

1064-1074

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EstB from Burkholderia gladioli: A novel esterase with a β-lactamase fold reveals steric factors to discriminate between esterolytic and β-lactam cleaving activity

11 February 2020

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Directed evolution converts subtilisin E into a functional equivalent of thermitase

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Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.

29 September 2017

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Computational design of the Fyn SH3 domain with increased stability through optimization of surface charge charge interactions

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Improving simvastatin bioconversion in Escherichia coli by deletion of bioH.

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Directed evolution of D-sialic acid aldolase to L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolase

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Modification of post-PKS tailoring steps through combinatorial biosynthesis

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A novel esterase from Burkholderia gladioli which shows high deacetylation activity on cephalosporins is related to beta-lactamases and DD-peptidases

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Of barn owls and bankers: a lush variety of alpha/beta hydrolases

29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

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Profiling a Taxol pathway 10beta-acetyltransferase: assessment of the specificity and the production of baccatin III by in vivo acetylation in E. coli.

27 November 2018

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Direct random mutagenesis of gene-sized DNA fragments using polymerase chain reaction

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19875080

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19875080

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A rapid technique for screening of lovastatin-producing strains of Aspergillus terreus by agar plug and Neurospora crassa bioassay

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19875080

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2009.09.017

2 references

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11 February 2020

1 reference

2 references

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11 February 2020

PubMed publication ID

19875080

2 references