Acetylcholinesterase: From 3D structure to function (Q27659614)

2

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Joel L. Sussman

object named as

Joel L Sussman

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author name string

Hay Dvir

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Michal Harel

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Terrone L Rosenberry

Chemico-biological Interactions

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language of work or name

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6 September 2010

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published in

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volume

187

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issue

1-3

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page(s)

10-22

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cites work

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The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix

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Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

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X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement

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Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

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Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

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Three-dimensional structures ofDrosophila melanogasteracetylcholinesterase and of its complexes with two potent inhibitors

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Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme

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Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

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Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex

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Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

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Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

20 March 2017

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The alpha/beta hydrolase fold

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The anatomy and taxonomy of protein structure

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Modes of attachment of acetylcholinesterase to the surface membrane

29 September 2017

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Acetylcholine binding by a synthetic receptor: implications for biological recognition

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Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

20 March 2017

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Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

20 March 2017

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Structural patterns in globular proteins

20 March 2017

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PRiMA: the membrane anchor of acetylcholinesterase in the brain

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Molecular basis of inhibition of substrate hydrolysis by a ligand bound to the peripheral site of acetylcholinesterase

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Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics

29 September 2017

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The hydration of the neurotransmitter acetylcholine in aqueous solution

29 September 2017

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Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease

29 September 2017

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The origin of the molecular diversity and functional anchoring of cholinesterases

29 September 2017

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Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase

29 September 2017

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A modular treatment of molecular traffic through the active site of cholinesterase

29 September 2017

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A four-to-one association between peptide motifs: four C-terminal domains from cholinesterase assemble with one proline-rich attachment domain (PRAD) in the secretory pathway

29 September 2017

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The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER

29 September 2017

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An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase

29 September 2017

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Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase

29 September 2017

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Crystallographic and NMR studies of the serine proteases

29 September 2017

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Specific photoaffinity labeling induced by energy transfer: application to irreversible inhibition of acetylcholinesterase

29 September 2017

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Structural basis of antibody function

29 September 2017

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Structure and mechanism of copper, zinc superoxide dismutase

29 September 2017

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Molecular Structures of Acetylcholinesterase from Electric Organ Tissue of the Electric Eel

29 September 2017

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Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium

29 September 2017

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Structure of human pancreatic lipase

29 September 2017

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Primary structure of a collagenic tail peptide of Torpedo acetylcholinesterase: co-expression with catalytic subunit induces the production of collagen-tailed forms in transfected cells

29 September 2017

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Asymmetric and globular forms of acetylcholinesterase in mammals and birds

29 September 2017

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Molecular structure of elongated forms of electric eel acetylcholinesterase

29 September 2017

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"Nonspecific" cholinesterase and acetylcholinesterase in rat tissues: molecular forms, structural and catalytic properties, and significance of the two enzyme systems

29 September 2017

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Interaction of ligands with acetylcholinesterase. Use of temperature-jump relaxation kinetics in the binding of specific fluorescent ligands

29 September 2017

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The mammalian gene of acetylcholinesterase-associated collagen

29 September 2017

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Quaternary associations of acetylcholinesterase. II. The polyproline attachment domain of the collagen tail

2 June 2018

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Developmental Regulation of Acetylcholinesterase Transcripts in the Mouse Diaphragm: Alternative Splicing and Focalization

2 June 2018

1 reference

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Ligand binding properties of acetylcholinesterase determined with fluorescent probes.

2 June 2018

1 reference

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Primary structures of the catalytic subunits from two molecular forms of acetylcholinesterase. A comparison of NH2-terminal and active center sequences

2 June 2018

1 reference

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Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

2 June 2018

1 reference

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Single gene encodes glycophospholipid-anchored and asymmetric acetylcholinesterase forms: alternative coding exons contain inverted repeat sequences

2 June 2018

1 reference

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Ligand exclusion on acetylcholinesterase

2 June 2018

1 reference

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Identification of discrete disulfide-linked oligomers which distinguish 18 S from 14 S acetylcholinesterase

2 June 2018

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2 June 2018

Acetylcholinesterase.

1 reference

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Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design

2 June 2018

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Selective adsorption of poly(ethylene oxide) onto a charged surface mediated by alkali metal ions

27 November 2018

1 reference

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The enzymic hydrolysis and synthesis of acetylcholine.

27 November 2018

1 reference

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The C-terminal t peptide of acetylcholinesterase forms an alpha helix that supports homomeric and heteromeric interactions

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894301

Unmasking Tandem Site Interaction in Human Acetylcholinesterase. Substrate Activation with a Cationic Acetanilide Substrate

27 November 2018

1 reference

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Acetylcholinesterase in motion: Visualizing conformational changes in crystal structures by a morphing procedure

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894301

External and internal electrostatic potentials of cholinesterase models

27 November 2018

1 reference

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Effective charge on acetylcholinesterase active sites determined from the ionic strength dependence of association rate constants with cationic ligands.

27 November 2018

1 reference

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Conformations of acetylcholine.

27 November 2018

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Molecular forms of Electrophorus acetylcholinesterase the catalytic subunits: fragmentation, intra- and inter-subunit disulfide bonds

27 November 2018

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12 December 2020

Organophosphorylation of acetylcholinesterase in the presence of peripheral site ligands. Distinct effects of propidium and fasciculin

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12 December 2020

Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway

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12 December 2020

Acetylcholinesterase: The structure of crystals of a globular form from electric eel

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12 December 2020

Spectral evidence for the presence of tryptophan in the binding site of acetylcholinesterase

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12 December 2020

Trimerization domain of the collagen tail of acetylcholinesterase

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12 December 2020

Acetylcholinesterase studies on molecular complementariness

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12 December 2020

The inhibitory effect of stilbamidine, curare and related compounds and its relationship to the active groups of acetylcholine esterase; action of stilbamidine upon nerve impulse conduction

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12 December 2020

Acetylcholinesterase. VIII. Dissociation constants of the active groups

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12 December 2020

Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum

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12 December 2020

Structure of wheat serine carboxypeptidase II at 3.5-A resolution. A new class of serine proteinase

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C

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12 December 2020

X-ray crystallographic structure of dienelactone hydrolase at 2.8 A

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12 December 2020

Crystallization and preliminary X-ray diffraction analysis of 11 S acetylcholinesterase

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12 December 2020

Acetylcholinesterase from bovine caudate nucleus is attached to membranes by a novel subunit distinct from those of acetylcholinesterases in other tissues

1 reference

12 December 2020

Tetrameric detergent-soluble acetylcholinesterase from human caudate nucleus: subunit composition and number of active sites

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12 December 2020

Profile of the disulfide bonds in acetylcholinesterase

1 reference

12 December 2020

Acetylcholinesterase: inhibition by tetranitromethane and arsenite. Binding of arsenite by tyrosine residues

1 reference

12 December 2020

Chemical modification of electric eel acetylcholinesterase by tetranitromethane

1 reference

12 December 2020

[Electron microscopic studies on stretched and globular acetylcholinesterase molecules of the electric eel (Electrophorus electricus)]

1 reference

12 December 2020

Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle

1 reference

12 December 2020

Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs

1 reference

12 December 2020

Inactivation of electric eel acetylcholinesterase by acylation with N-hydroxysuccinimide esters of amino acid derivatives

1 reference

12 December 2020

A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C

1 reference

12 December 2020

Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect

1 reference

12 December 2020

10.1016/J.CBI.2010.01.042

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

20138030

1 reference