Structural determinants of growth factor binding and specificity by VEGF receptor 2 (Q27659686)

10

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Veli-Matti Leppänen

1

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Michael Jeltsch

3

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Kurt Ballmer-Hofer

9

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Hilkka Lankinen

7

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Nisse Kalkkinen

5

object named as

Nisse Kalkkinen

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author name string

Andrea E Prota

2

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Andrey Anisimov

4

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Tomas Strandin

6

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Adrian Goldman

Proceedings of the National Academy of Sciences of the United States of America

8

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language of work or name

English

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publication date

9 February 2010

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published in

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volume

107

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issue

6

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page(s)

2425-30

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cites work

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Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

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Proteolytic processing regulates receptor specificity and activity of VEGF-C.

20 March 2017

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A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

20 March 2017

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Crystal structure of human platelet-derived growth factor BB

20 March 2017

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Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

20 March 2017

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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

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Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains

20 March 2017

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Molecular regulation of angiogenesis and lymphangiogenesis

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Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers

7 April 2017

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Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle

29 September 2017

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Novel vascular endothelial growth factor D variants with increased biological activity

29 September 2017

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VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

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Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues

29 September 2017

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Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

29 September 2017

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Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

29 September 2017

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Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR.

29 September 2017

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VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.

29 September 2017

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A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.

29 September 2017

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29 September 2017

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Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding

29 September 2017

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Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns

29 September 2017

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29 September 2017

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Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis

29 September 2017

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29 September 2017

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Vascular endothelial growth factors encoded by Orf virus show surprising sequence variation but have a conserved, functionally relevant structure.

29 September 2017

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Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules

29 September 2017

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A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities

29 September 2017

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Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus

29 September 2017

1 reference

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Structure of a VEGF-VEGF receptor complex determined by electron microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823880

Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823880

A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823880

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823880

Viral Vascular Endothelial Growth Factors Vary Extensively in Amino Acid Sequence, Receptor-binding Specificities, and the Ability to Induce Vascular Permeability yet Are Uniformly Active Mitogens

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823880

Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823880

27 November 2018

Identifiers

DOI

10.1073/PNAS.0914318107

1 reference

release_2wekphm6tvdzrihkzvzq3kh36q

0 references

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4843951

1 reference

1 reference

1 reference