An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein (Q27663961)

2

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Rachel C Steinhardt

3

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Michael R Schamber

4

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Frederick A Dick

5

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Seth M Rubin

Nature Structural & Molecular Biology

6

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publication date

September 2010

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published in

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volume

17

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issue

9

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page(s)

1051-7

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describes a project that uses

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2933323/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release

20 March 2017

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Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A

20 March 2017

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Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

20 March 2017

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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

20 March 2017

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

20 March 2017

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Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

20 March 2017

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20 March 2017

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The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

20 March 2017

1 reference

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The retinoblastoma protein and cell cycle control

20 March 2017

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Protein phosphatase 1--targeted in many directions

20 March 2017

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

20 March 2017

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Structural basis of protein phosphatase 1 regulation

20 March 2017

1 reference

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The regulation of E2F by pRB-family proteins

20 March 2017

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Retinoblastoma protein recruits histone deacetylase to repress transcription

20 March 2017

1 reference

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Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

20 March 2017

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20 March 2017

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Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

22 April 2017

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20 March 2017

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Principles of CDK regulation

7 April 2017

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Rb targets histone H3 methylation and HP1 to promoters

7 April 2017

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

7 April 2017

1 reference

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Distinct roles for cyclin-dependent kinases in cell cycle control

7 April 2017

1 reference

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Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

7 April 2017

1 reference

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Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding

7 April 2017

1 reference

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Unlimited multistability in multisite phosphorylation systems

29 September 2017

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Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A.

29 September 2017

1 reference

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pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption

29 September 2017

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Competition effects shape the response sensitivity and kinetics of phosphorylation cycles in cell signaling

29 September 2017

1 reference

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An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant

29 September 2017

1 reference

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PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation

29 September 2017

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The retinoblastoma tumour suppressor in development and cancer

29 September 2017

1 reference

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RB activation defect in tumor cell lines

29 September 2017

1 reference

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Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

The carboxyl-terminal region of the retinoblastoma protein binds non-competitively to protein phosphatase type 1alpha and inhibits catalytic activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Binding of select forms of pRB to protein phosphatase type 1 independent of catalytic activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Purification and reconstitution of cyclin-dependent kinase 2 in four states of activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

High molecular weight protein phosphatase type 1 dephosphorylates the retinoblastoma protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Specific enzymatic dephosphorylation of the retinoblastoma protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Expression of recombinant inhibitor-2 in E. coli and its utilization for the affinity chromatography of protein phosphatase-1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933323

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

27 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.1868

Dephosphorylation of Rb (Thr-821) in response to cell stress

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.1868

31 March 2020

Identifiers

DOI

10.1038/NSMB.1868

1 reference

Dimensions Publication ID

3333645

1007081028

0 references

3333645

1 reference

1 reference

1 reference