Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing (Q27666758)

4

0 references

Damian Szklarczyk

7

0 references

Lars Juhl Jensen

8

0 references

Andreas Eisenreich

Andreas Eisenreich

3

0 references

Kilian Huber

Kilian Huber

2

0 references

Oleg Fedorov

Oleg Fedorov

1

0 references

Stefan Knapp

Stefan Knapp

13

0 references

Oliver King

Oliver King

5

0 references

Ursula Rauch

11

Ursula Rauch

0 references

Doriano Fabbro

9

Doriano Fabbro

0 references

Jörg Trappe

10

Jörg Trappe

0 references

Franz Bracher

12

Franz Bracher

0 references

author name string

Alex N Bullock

The pathobiology of splicing

6

0 references

publication date

28 January 2011

0 references

published in

Chemistry and Biology

0 references

volume

18

0 references

issue

1

0 references

page(s)

67-76

0 references

cites work

1 reference

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Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

20 March 2017

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Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells

20 March 2017

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Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors

20 March 2017

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20 March 2017

A short history of SHELX

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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

20 March 2017

1 reference

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Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

20 March 2017

1 reference

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The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

20 March 2017

1 reference

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A serine kinase regulates intracellular localization of splicing factors in the cell cycle

20 March 2017

1 reference

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

20 March 2017

1 reference

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Likelihood-enhanced fast translation functions

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Automated protein model building combined with iterative structure refinement

20 March 2017

1 reference

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The spliceosome: design principles of a dynamic RNP machine

20 March 2017

1 reference

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Mechanisms of alternative pre-messenger RNA splicing

20 March 2017

1 reference

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Extended kinase profile and properties of the protein kinase inhibitor nilotinib

20 March 2017

1 reference

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A quantitative analysis of kinase inhibitor selectivity

20 March 2017

1 reference

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Manipulation of alternative splicing by a newly developed inhibitor of Clks

20 March 2017

1 reference

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Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid

20 March 2017

1 reference

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The SR protein family of splicing factors: master regulators of gene expression

20 March 2017

1 reference

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A small molecule-kinase interaction map for clinical kinase inhibitors

7 April 2017

1 reference

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A medicinal chemist's guide to molecular interactions

7 April 2017

1 reference

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Halogen atoms in the modern medicinal chemistry: hints for the drug design.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Selectively nonselective kinase inhibition: striking the right balance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Spliceosome structure: piece by piece

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Measuring and interpreting the selectivity of protein kinase inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

VEGF-A splicing: the key to anti-angiogenic therapeutics?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Regulation of alternative splicing by reversible protein phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

The role of halogen bonding in inhibitor recognition and binding by protein kinases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Signals, pathways and splicing regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Alternative splicing: an emerging topic in molecular and clinical oncology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Direct phase determination by entropy maximization and likelihood ranking: status report and perspectives

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Inhibitors of PIM-1 kinase: a computational analysis of the binding free energies of a range of imidazo [1,2-b] pyridazines.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

beta-Carbolines from the blue-green alga Dichothrix baueriana.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145970

Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21276940

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21276940

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of the Cdc2-like kinase-family and DNA topoisomerase I on the alternative splicing of eNOS in TNF-alpha-stimulated human endothelial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21276940

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2010.11.009

1 reference

1 reference

1 reference

PubMed publication ID

21276940

1 reference