KSR and CNK: two scaffolds regulating RAS-mediated RAF activation (Q36819377)

16 August 2017

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title

KSR and CNK: two scaffolds regulating RAS-mediated RAF activation (English)

1 reference

16 August 2017

Clapéron A

1

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PubMed ID

17496912

16 August 2017

Therrien M

series ordinal

2

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PubMed ID

17496912

16 August 2017

language of work or name

English

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publication date

1 May 2007

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16 August 2017

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16 August 2017

26

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16 August 2017

22

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16 August 2017

3143-3158

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210408

16 August 2017

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cites work

Critical contribution of linker proteins to Raf kinase activation

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7 January 2021

DER signaling restricts the boundaries of the wing field during Drosophila development

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7 January 2021

KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation

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Emerging roles of pseudokinases

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7 January 2021

Two distinct Raf domains mediate interaction with Ras

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7 January 2021

CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation.

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7 January 2021

Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila

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7 January 2021

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

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Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

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7 January 2021

14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila

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7 January 2021

hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation

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7 January 2021

Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling

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7 January 2021

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3

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7 January 2021

Positive and negative regulation of Raf kinase activity and function by phosphorylation

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7 January 2021

Mechanisms of regulating the Raf kinase family

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7 January 2021

C1 domains exposed: from diacylglycerol binding to protein-protein interactions

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Autoregulation of the Raf-1 serine/threonine kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Scaffold proteins in MAP kinase signaling: more than simple passive activating platforms.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Mutations of the BRAF gene in human cancer

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7 January 2021

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

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7 January 2021

Untying the regulation of the Raf-1 kinase

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7 January 2021

Regulation of Raf-1 activation and signalling by dephosphorylation

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7 January 2021

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

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7 January 2021

Bimodal regulation of RAF by CNK in Drosophila

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7 January 2021

A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila

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7 January 2021

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

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7 January 2021

New insights into the control of MAP kinase pathways

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7 January 2021

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

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7 January 2021

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Pleckstrin homology domains: not just for phosphoinositides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Evolution of protein kinase signaling from yeast to man

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

KSR stimulates Raf-1 activity in a kinase-independent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

PDZ Domain Proteins: Plug and Play!

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

KSR is a scaffold required for activation of the ERK/MAPK module

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Regulation and role of Raf-1/B-Raf heterodimerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

KSR, a novel protein kinase required for RAS signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

KSR modulates signal propagation within the MAPK cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

CNK, a RAF-binding multidomain protein required for RAS signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Functional analysis of CNK in RAS signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Regulatory mechanisms and function of ERK MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Signaling pathways for PC12 cell differentiation: making the right connections

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The RAF proteins take centre stage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

The protein kinase KSR interacts with 14-3-3 protein and Raf.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210408

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210408

1 reference

16 August 2017

1 reference

PubMed ID

17496912