Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production (Q27670714)

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English	Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production	scientific article

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scholarly article

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Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production (English)

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cell differentiation

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based on heuristic

inferred from title

author name string

Saori Fujita-Sato

1

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Shuichiro Ito

2

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Takashi Isobe

3

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Takao Ohyama

4

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Kenji Wakabayashi

5

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Kaoru Morishita

6

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Osamu Ando

7

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Fujio Isono

8

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language of work or name

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publication date

9 September 2011

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Journal of Biological Chemistry

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286

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31409-17

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36

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Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma

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Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

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20 March 2017

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

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X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch

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20 March 2017

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

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20 March 2017

Structural insights into the mode of action of a pure antiestrogen

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20 March 2017

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

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IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

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Molecular basis of agonism and antagonism in the oestrogen receptor

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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

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20 March 2017

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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20 March 2017

Coot: model-building tools for molecular graphics

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

The CCP4 suite: programs for protein crystallography

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20 March 2017

Principles for modulation of the nuclear receptor superfamily

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20 March 2017

Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element

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20 March 2017

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

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20 March 2017

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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7 April 2017

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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7 April 2017

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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7 April 2017

Development, cytokine profile and function of human interleukin 17-producing helper T cells

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7 April 2017

Phenotypic and functional features of human Th17 cells

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7 April 2017

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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7 April 2017

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

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7 April 2017

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

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29 September 2017

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173075

29 September 2017

A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)

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The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

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29 September 2017

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

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29 September 2017

Transcriptional regulation of Th17 cell differentiation

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29 September 2017

Expanding the effector CD4 T-cell repertoire: the Th17 lineage.

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Structural studies on nuclear receptors.

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29 September 2017

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

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29 September 2017

RORC2: the master of human Th17 cell programming.

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21 January 2018

Improvement of macrophage dysfunction by administration of anti-transforming growth factor-beta antibody in EL4-bearing hosts.

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Processing of X-ray diffraction data collected in oscillation mode

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Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

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Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells

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IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

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https://pubmed.ncbi.nlm.nih.gov/21733845

12 December 2020

based on heuristic

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The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

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12 December 2020

based on heuristic

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A canonical structure for the ligand-binding domain of nuclear receptors

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