Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel (Q27670838)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21765407%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel (English)

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7 February 2020

0 references

3

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7 February 2020

author name string

Fa Liu

1

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7 February 2020

Jung-Eun Park

2

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7 February 2020

Dan Lim

4

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7 February 2020

Martin Gräber

5

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7 February 2020

Thorsten Berg

6

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7 February 2020

Michael B Yaffe

7

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7 February 2020

Kyung S Lee

8

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7 February 2020

Terrence R Burke

9

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7 February 2020

publication date

17 July 2011

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7 February 2020

published in

Nature Chemical Biology

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7 February 2020

volume

7

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7 February 2020

issue

9

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7 February 2020

page(s)

595-601

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From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

7 February 2020

cites work

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Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation

20 March 2017

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Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

20 March 2017

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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

20 March 2017

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20 March 2017

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The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

20 March 2017

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The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

20 March 2017

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Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

20 March 2017

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Polo-like kinases: a team in control of the division

20 March 2017

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Polo-like kinases and the orchestration of cell division

20 March 2017

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Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

7 April 2017

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Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides

7 April 2017

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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

29 September 2017

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Delivery of therapeutic proteins

29 September 2017

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A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

29 September 2017

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The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation

29 September 2017

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Mitsunobu and related reactions: advances and applications

29 September 2017

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A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis

29 September 2017

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Polo-like kinases: conservation and divergence in their functions and regulation

29 September 2017

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Promiscuous aggregate-based inhibitors promote enzyme unfolding

29 September 2017

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Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry

29 September 2017

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Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

29 September 2017

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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

29 September 2017

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Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores

29 September 2017

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29 September 2017

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29 September 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation

21 January 2018

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The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21765407

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12 December 2020

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Identifiers

DOI

10.1038/NCHEMBIO.614

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Dimensions Publication ID

7 February 2020

1004249165

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Fatcat ID

release_sbjrsvtyv5cy3crqxd7kyezigu

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Fatcat

https://api.fatcat.wiki/v0/release/sbjrsvtyv5cy3crqxd7kyezigu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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7 February 2020

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